Saadat Aleem
Overview
Explore the profile of Saadat Aleem including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
6
Citations
107
Followers
0
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Recent Articles
1.
Al-Sadawi M, Aslam F, Gier C, Aleem S, Ijaz H, Jacobs R, et al.
Heart Rhythm O2
. 2023 Jun;
4(5):309-316.
PMID: 37323996
Background: Previous studies have shown that women with atrial fibrillation (AF) have a higher incidence of recurrence and non-pulmonary vein (non-PV) triggers. However, there remains an incomplete understanding of the...
2.
Rhythm versus rate control for atrial fibrillation in heart failure with preserved ejection fraction
Al-Sadawi M, Aleem S, Aslam F, Jacobs R, Stevens G, Almasry I, et al.
Heart Rhythm O2
. 2022 Nov;
3(5):520-525.
PMID: 36340484
Background: There are few prospective studies assessing the benefits of rhythm control of atrial fibrillation (AF) in patients with heart failure and preserved ejection fraction (HFpEF), which accounts for 50%...
3.
Aleem S, Georghiou G, Kleiner R, Guja K, Craddock B, Lyczek A, et al.
Cell Chem Biol
. 2016 Sep;
23(9):1103-1112.
PMID: 27593110
Protein kinases are attractive therapeutic targets because their dysregulation underlies many diseases, including cancer. The high conservation of the kinase domain and the evolution of drug resistance, however, pose major...
4.
Fan G, Aleem S, Yang M, Miller W, Tonks N
J Biol Chem
. 2015 Apr;
290(26):15934-47.
PMID: 25897081
Despite significant evidence to the contrary, the view that phosphatases are "nonspecific" still pervades the field. Systems biology approaches to defining how signal transduction pathways are integrated at the level...
5.
Dzierba C, Bi Y, Dasgupta B, Hartz R, Ahuja V, Cianchetta G, et al.
Bioorg Med Chem Lett
. 2015 Feb;
25(7):1448-52.
PMID: 25690789
Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia. A series of...
6.
Bagdanoff J, Donoviel M, Nouraldeen A, Carlsen M, Jessop T, Tarver J, et al.
J Med Chem
. 2010 Nov;
53(24):8650-62.
PMID: 21090716
Sphingosine 1-phosphate lyase (S1PL) has been characterized as a novel target for the treatment of autoimmune disorders using genetic and pharmacological methods. Medicinal chemistry efforts targeting S1PL by direct in...