S Skwish
Overview
Explore the profile of S Skwish including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
11
Citations
34
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Washburn W, Harper T, Wu G, Godfrey J, McCann P, Girotra R, et al.
Bioorg Med Chem Lett
. 2007 May;
17(15):4290-6.
PMID: 17533126
Utilization of N-substituted-4-hydroxy-3-methylsulfonanilidoethanolamines 1 as selective beta(3) agonists is complicated by their propensity to undergo metabolic oxidative N-dealkylation, generating 0.01-2% of a very potent alpha(1) adrenergic agonist 2. A summary...
2.
Washburn W, Sun C, Bisacchi G, Wu G, Cheng P, Sher P, et al.
Bioorg Med Chem Lett
. 2004 Jun;
14(13):3525-9.
PMID: 15177466
A series of N-(4-hydroxy-3-methylsulfonanilidoethanol)arylglycinamides were prepared and evaluated for their human beta3 adrenergic receptor agonist activity. SAR studies led to the identification of BMS-201620 (39), a potent beta3 full agonist...
3.
Gavai A, Sher P, Mikkilineni A, Poss K, McCann P, Girotra R, et al.
Bioorg Med Chem Lett
. 2001 Nov;
11(23):3041-4.
PMID: 11714606
A series of 4-hydroxy-3-methylsulfonanilido-1,2-diarylethylamines were prepared and evaluated for their human beta(3) adrenergic receptor agonist activity. SAR studies led to the identification of BMS-196085 (25), a potent beta(3) full agonist...
4.
Washburn W, Sher P, Poss K, Girotra R, McCann P, Gavai A, et al.
Bioorg Med Chem Lett
. 2001 Nov;
11(23):3035-9.
PMID: 11714605
Screening of the BMS collection identified 4-hydroxy-3-methylsulfonanilidoethanolamines as full beta 3 agonists. Substitution of the ethanolamine nitrogen with a benzyl group bearing a para hydrogen bond acceptor promoted beta(3) selectivity....
5.
Clarke G, Feiglin M, King G, Bishop J, Skwish S, Kath G
J Biomol Screen
. 2001 Nov;
6(5):333-8.
PMID: 11689133
With the improved reliability and efficiency of automation, there has been an increased desire to integrate automated sample management with automated screening systems. In order to store samples "on line"...
6.
Feiglin M, Skwish S, Laab M, Heppel A
J Biomol Screen
. 2000 Jun;
5(1):39-48.
PMID: 10841599
As automation solves the bottleneck involved in drug screening, new bottlenecks present themselves. Some of these bottlenecks include sample management, hit picking and confirmation, and reagents lost as a result...
7.
Zuck P, Lao Z, Skwish S, Glickman J, Yang K, Burbaum J, et al.
Proc Natl Acad Sci U S A
. 1999 Sep;
96(20):11122-7.
PMID: 10500140
This report describes the integration of laser-scanning fluorometric cytometry and nonseparation ligand-binding techniques to provide new assay methods adaptable to miniaturization and high-throughput screening. Receptor-bound, cyanine dye-labeled ligands, [Cy]ligands, were...
8.
Meyers D, Skwish S, Dickinson K, Kienzle B, Arbeeny C
J Clin Endocrinol Metab
. 1997 Feb;
82(2):395-401.
PMID: 9024225
Primary adipocytes were isolated from axillary brown adipose tissue from adult cynomolgus monkeys. That this tissue contained brown adipocytes was verified by morphological examination and by demonstrating the presence of...
9.
Webb M, Patel P, Rose P, Liu E, Stein P, Barrish J, et al.
Biochemistry
. 1996 Feb;
35(8):2548-56.
PMID: 8611558
Endothelin (ET) receptor antagonism is a potential therapeutic intervention in the treatment of vascular diseases. To elucidate the mechanism of antagonist-ET receptor complex formation, the interactions of four chemically distinct...
10.
Dickinson K, Cohen R, Skwish S, Delaney C, Serafino R, Poss M, et al.
Br J Pharmacol
. 1994 Sep;
113(1):179-89.
PMID: 7812609
1. This study compares the activity of BMS-180560 (2-butyl-1-chloro-1-[[1-[2-(2H-tetrazol-5-yl)phenyl]-1H-indol-4- yl]methyl]-1H-imidazole-5-carboxylic acid), an insurmountable angiotensin II (AII) receptor antagonist, with that of losartan and EXP3174 in functional and biochemical models of...