S Sean Millard
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Explore the profile of S Sean Millard including associated specialties, affiliations and a list of published articles.
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25
Citations
626
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Recent Articles
1.
Schendel V, Hamilton B, Robinson S, Green K, Sayre M, Brown D, et al.
Nat Ecol Evol
. 2024 Nov;
9(1):73-86.
PMID: 39496866
Venoms are biochemical arsenals that have emerged in numerous animal lineages, where they have co-evolved with morphological and behavioural traits for venom production and delivery. In centipedes, venom evolution is...
2.
Odierna G, Kerwin S, Shin G, Millard S
Front Mol Neurosci
. 2024 Aug;
17:1415207.
PMID: 39092203
Recent studies capitalizing on the newly complete nanometer-resolution larval connectome have made significant advances in identifying the structural basis of motor patterning. However, the molecular mechanisms utilized by neurons to...
3.
Nguyen-Dien G, Townsend B, Kulkarni P, Kozul K, Ooi S, Eldershaw D, et al.
EMBO Rep
. 2024 Jul;
25(8):3324-3347.
PMID: 38992176
Mitophagy must be carefully regulated to ensure that cells maintain appropriate numbers of functional mitochondria. The SCF ubiquitin ligase complex suppresses mitophagy by controlling the degradation of BNIP3 and NIX...
4.
Dark C, Ali N, Golenkina S, Dhyani V, Blazev R, Parker B, et al.
EMBO Rep
. 2024 Mar;
25(4):1835-1858.
PMID: 38429578
Cancer cachexia is a tumour-induced wasting syndrome, characterised by extreme loss of skeletal muscle. Defective mitochondria can contribute to muscle wasting; however, the underlying mechanisms remain unclear. Using a Drosophila...
5.
Nguyen-Dien G, Kozul K, Cui Y, Townsend B, Kulkarni P, Ooi S, et al.
EMBO J
. 2023 May;
42(13):e112767.
PMID: 37161784
To maintain both mitochondrial quality and quantity, cells selectively remove damaged or excessive mitochondria through mitophagy, which is a specialised form of autophagy. Mitophagy is induced in response to diverse...
6.
Galindo S, Shin G, Millard S, Grueber W
bioRxiv
. 2023 Mar;
PMID: 36909552
Axon and dendrite placement and connectivity is guided by a wide range of secreted and surface molecules in the developing nervous system. Nevertheless, the extraordinary complexity of connections in the...
7.
Odierna G, Kerwin S, Harris L, Shin G, Lavidis N, Noakes P, et al.
J Cell Biol
. 2020 Apr;
219(6).
PMID: 32259198
Dscam2 is a cell surface protein required for neuronal development in Drosophila; it can promote neural wiring through homophilic recognition that leads to either adhesion or repulsion between neurites. Here,...
8.
Shohayeb B, Mitchell N, Millard S, Quinn L, Ng D
Biochim Biophys Acta Mol Cell Res
. 2020 Apr;
1867(7):118713.
PMID: 32246948
WD40-Repeat Protein 62 (WDR62) is required to maintain neural and glial cell populations during embryonic brain growth. Although elevated expression of WDR62 is frequently associated with several tumour types, potential...
9.
Shohayeb B, Ho U, Yeap Y, Parton R, Millard S, Xu Z, et al.
Hum Mol Genet
. 2019 Dec;
29(2):248-263.
PMID: 31816041
WDR62 mutations that result in protein loss, truncation or single amino-acid substitutions are causative for human microcephaly, indicating critical roles in cell expansion required for brain development. WDR62 missense mutations...
10.
Shun Li J, Millard S
Sci Adv
. 2019 Feb;
5(1):eaav1678.
PMID: 30746474
Alternative splicing increases the proteome diversity crucial for establishing the complex circuitry between trillions of neurons. To provide individual cells with different repertoires of protein isoforms, however, this process must...