S S Bhagwat
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Explore the profile of S S Bhagwat including associated specialties, affiliations and a list of published articles.
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25
Citations
1096
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Recent Articles
1.
Bhagwat S, Periasamy H, Takalkar S, Palwe S, Khande H, Patel M
Antimicrob Agents Chemother
. 2019 Jan;
63(4).
PMID: 30670419
WCK 5222 is a combination of cefepime and the high-affinity PBP2-binding β-lactam enhancer zidebactam. The cefepime-zidebactam combination is active against multidrug-resistant Gram-negative bacteria, including carbapenemase-expressing The mechanism of action of...
2.
Samant B, Saraf Y, Bhagwat S
J Colloid Interface Sci
. 2006 Jun;
302(1):207-13.
PMID: 16806254
Chlorination of phenol and ortho-chlorophenol was studied in micellar media in order to observe the effect on regioselectivity. Hydrogen peroxide/hydrochloric acid-aqueous system, which is environmentally a safer route was employed...
3.
Sutherland M, Brady H, Gayo-Fung L, Leisten J, Lipps S, McKie J, et al.
Calcif Tissue Int
. 2003 Oct;
72(6):710-6.
PMID: 14563000
We describe here the activity of a novel selective estrogen receptor modulator, SP500263. When given to adult ovariectomized (OVX) rats for 28 days at doses of 0.3, 1, or 3...
4.
Bennett B, Sasaki D, Murray B, OLeary E, Sakata S, Xu W, et al.
Proc Natl Acad Sci U S A
. 2001 Nov;
98(24):13681-6.
PMID: 11717429
Jun N-terminal kinase (JNK) is a stress-activated protein kinase that can be induced by inflammatory cytokines, bacterial endotoxin, osmotic shock, UV radiation, and hypoxia. We report the identification of an...
5.
Lee C, Daanen J, Jiang M, Yu H, Kohlhaas K, Alexander K, et al.
Bioorg Med Chem Lett
. 2001 Sep;
11(18):2419-22.
PMID: 11549437
Adenosine kinase (AK) is the primary enzyme responsible for adenosine metabolism. Inhibition of AK effectively increases extracellular adenosine concentrations and represents an alternative approach to enhance the beneficial actions of...
6.
Zheng G, Lee C, Pratt J, Perner R, Jiang M, Gomtsyan A, et al.
Bioorg Med Chem Lett
. 2001 Aug;
11(16):2071-4.
PMID: 11514141
A novel series of pyridopyrimidine analogues 9 was identified as potent adenosine kinase inhibitors based on the SAR and computational studies. Substitution of the C7 position of the pyridopyrimidino core...
7.
Lee C, Jiang M, Cowart M, Gfesser G, Perner R, Kim K, et al.
J Med Chem
. 2001 Jun;
44(13):2133-8.
PMID: 11405650
Adenosine (ADO) is an endogenous homeostatic inhibitory neuromodulator that reduces cellular excitability at sites of tissue injury and inflammation. Inhibition of adenosine kinase (AK), the primary metabolic enzyme for ADO,...
8.
Boyle D, Kowaluk E, Jarvis M, Lee C, Bhagwat S, Williams M, et al.
J Pharmacol Exp Ther
. 2001 Feb;
296(2):495-500.
PMID: 11160636
Adenosine (ADO) is a homeostatic inhibitory autocoid that is released at sites of inflammation and tissue injury, and exerts anti-inflammatory effects via multiple interactions at ADO receptor subtypes. Inhibition of...
9.
Cowart M, Lee C, Gfesser G, Bayburt E, Bhagwat S, Stewart A, et al.
Bioorg Med Chem Lett
. 2001 Jan;
11(1):83-6.
PMID: 11140740
The synthesis and SAR of a novel series of non-nucleoside pyridopyrimidine inhibitors of the enzyme adenosine kinase (AK) are described. It was found that pyridopyrimidines with a broad range of...
10.
Kowaluk E, Mikusa J, Wismer C, Zhu C, Schweitzer E, Lynch J, et al.
J Pharmacol Exp Ther
. 2000 Nov;
295(3):1165-74.
PMID: 11082454
Adenosine kinase (AK; EC 2.7.1.20) is a key intracellular enzyme regulating intra-and extracellular concentrations of adenosine (ADO), an endogenous neuromodulator, antinociceptive, and anti-inflammatory autocoid. AK inhibition provides a means of...