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S R Hugl

Explore the profile of S R Hugl including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 249
Followers 0
Related Specialties
Biochemistry
Endocrinology
Nursing
Top 10 Co-Authors
C J Rhodes
M G Myers Jr
M F White
S P Cousin
M Merger
A Reifel-Miller
J Scholmerich
L C Bollheimer
C G Hammerschmied
H Kajio
Published In
J Biol Chem
Endocrinology
Krankenpfl J
J Mol Endocrinol
Biochem J
Affiliations
Soon will be listed here.
Recent Articles
1.
Hepatocyte growth factor stimulates proliferation of pancreatic beta-cells particularly in the presence of subphysiological glucose concentrations
Gahr S, Merger M, Bollheimer L, Hammerschmied C, Scholmerich J, Hugl S
J Mol Endocrinol . 2002 Apr; 28(2):99-110. PMID: 11932207
We investigated the role of hepatocyte growth factor (HGF) in beta-cell growth and its complex intracellular signal transduction pathways. Cell proliferation was measured in the beta-cell line INS-1 using [3H]thymidine...
2.
Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1)
Dickson L, Lingohr M, McCuaig J, Hugl S, Snow L, Kahn B, et al.
J Biol Chem . 2001 Mar; 276(24):21110-20. PMID: 11274216
It has been shown that IGF-1-induced pancreatic beta-cell proliferation is glucose-dependent; however, the mechanisms responsible for this glucose dependence are not known. Adenoviral mediated expression of constitutively active phosphatidylinositol 3-kinase...
3.
Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1
Cousin S, Hugl S, Wrede C, Kajio H, Myers Jr M, Rhodes C
Endocrinology . 2001 Jan; 142(1):229-40. PMID: 11145586
Pancreatic beta-cell mitogenesis is increased by insulin-like growth factor I (IGF-I) in a glucose-dependent manner. In this study it was found that alternative beta-cell nutrient fuels to glucose, pyruvate, and...
4.
Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor...
Cousin S, Hugl S, Myers Jr M, White M, Reifel-Miller A, Rhodes C
Biochem J . 1999 Dec; 344 Pt 3:649-58. PMID: 10585851
Mitogenic signal-transduction pathways have not been well defined in pancreatic beta-cells. In the glucose-sensitive rat beta-cell line, INS-1, glucose (6-18 mM) increased INS-1 cell proliferation (>20-fold at 15 mM glucose)....
5.
[What is new about diabetes mellitus, type 2?]
Hugl S, Palitzsch K
Krankenpfl J . 1999 Oct; 37(6):223-5. PMID: 10524088
No abstract available.
6.
Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells
Hugl S, White M, Rhodes C
J Biol Chem . 1998 Jul; 273(28):17771-9. PMID: 9651378
Nutrients and certain growth factors stimulate pancreatic beta-cell mitogenesis, however, the appropriate mitogenic signal transduction pathways have not been defined. In the glucose-sensitive pancreatic beta-cell line, INS-1, it was found...