S R Doctrow
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Explore the profile of S R Doctrow including associated specialties, affiliations and a list of published articles.
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28
Citations
888
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Recent Articles
1.
Raber J, Davis M, Pfankuch T, Rosenthal R, Doctrow S, Moulder J
Behav Brain Res
. 2016 Oct;
320:457-463.
PMID: 27789343
The brain could be exposed to irradiation as part of a nuclear accident, radiological terrorism (dirty bomb scenario) or a medical radiological procedure. In the context of accidents or terrorism,...
2.
Mahmood J, Jelveh S, Zaidi A, Doctrow S, Hill R
Radiat Res
. 2012 Dec;
179(2):125-34.
PMID: 23237541
Exposure of civilian populations to radiation due to accident, war or terrorist act is an increasing concern. The lung is one of the more radiosensitive organs that may be affected...
3.
Mahmood J, Jelveh S, Calveley V, Zaidi A, Doctrow S, Hill R
Radiat Res
. 2011 Oct;
176(6):770-80.
PMID: 22013884
There is a serious need to develop effective mitigators against accidental radiation exposures. In radiation accidents, many people may receive nonuniform whole-body or partial-body irradiation. The lung is one of...
4.
Limoli C, Giedzinski E, Baure J, Doctrow S, Rola R, Fike J
Radiat Prot Dosimetry
. 2006 Dec;
122(1-4):228-36.
PMID: 17166877
Past work has shown that neural precursor cells are predisposed to redox sensitive changes, and that oxidative stress plays a critical role in the acute and persistent changes that occur...
5.
Rupniak H, Joy K, Atkin C, Brown G, Barnes J, Doctrow S, et al.
Neurotox Res
. 2006 Jun;
2(2-3):167-78.
PMID: 16787839
Considerable evidence exists that the brains of individuals with Alzheimer's disease are subject to elevated levels of oxidative stress, particularly in regions exhibiting pathological damage. A major contributor to this...
6.
Melov S, Doctrow S, Schneider J, Haberson J, Patel M, Coskun P, et al.
J Neurosci
. 2001 Oct;
21(21):8348-53.
PMID: 11606622
Superoxide is produced as a result of normal energy metabolism within the mitochondria and is scavenged by the mitochondrial form of superoxide dismutase (sod2). Mice with inactivated SOD2 (sod2 nullizygous...
7.
Pong K, Doctrow S, Huffman K, Adinolfi C, Baudry M
Exp Neurol
. 2001 Aug;
171(1):84-97.
PMID: 11520123
Neuronal apoptosis induced by staurosporine (STS) involves multiple cellular and molecular events, such as the production of reactive oxygen species (ROS). In this study, we tested the efficacy of two...
8.
Giblin G, Box P, Campbell I, Hancock A, Roomans S, Mills G, et al.
Bioorg Med Chem Lett
. 2001 May;
11(11):1367-70.
PMID: 11378356
A series of novel manganese(III) complexes is described based on a 6,6'-bis(2-hydroxyphenyl)-2,2'-bipyridine template. These complexes show superoxide dismutase and catalase activity. The effect of the aromatic substitution pattern on the...
9.
Pong K, Doctrow S, Baudry M
Brain Res
. 2000 Oct;
881(2):182-9.
PMID: 11036157
Oxidative stress has been implicated in the selective degeneration of dopaminergic (DAergic) neurons in Parkinson's disease (PD). In this study, we tested the efficacy of EUK-134, a superoxide dismutase (SOD)...
10.
Melov S, Ravenscroft J, Malik S, Gill M, Walker D, Clayton P, et al.
Science
. 2000 Sep;
289(5484):1567-9.
PMID: 10968795
We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased...