S R Coughlin
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Explore the profile of S R Coughlin including associated specialties, affiliations and a list of published articles.
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100
Citations
6932
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Recent Articles
1.
Coughlin S
Trends Cardiovasc Med
. 2011 Jan;
4(2):77-83.
PMID: 21244899
Thrombin, a multifunctional protease generated at sites of vascular injury, is a powerful agonist fora variety of cellular processes important in cardiovascular disease. A recently cloned thrombin receptor has provided...
2.
Hamilton J, Cornelissen I, Mountford J, Coughlin S
Atherosclerosis
. 2009 Feb;
205(2):427-32.
PMID: 19217621
Platelet activation has long been postulated to contribute to the development of atherosclerotic plaques, although the mechanism by which this might occur remains unknown. Thrombin is a potent platelet activator...
3.
Coughlin S, Mawdsley L, Mugarza J, Wilding J, Calverley P
Eur Respir J
. 2007 Jan;
29(4):720-7.
PMID: 17251237
Obstructive sleep apnoea is associated with increased blood pressure and other features of the metabolic syndrome. The aim of the present study was to determine the relative effectiveness of continuous...
4.
Coughlin S
J Thromb Haemost
. 2005 Aug;
3(8):1800-14.
PMID: 16102047
The coagulation cascade and protease-activated receptors (PARs) together provide an elegant mechanism that links mechanical information in the form of tissue injury to cellular responses. These receptors appear to largely...
5.
Hamilton J, Cornelissen I, Coughlin S
J Thromb Haemost
. 2004 Aug;
2(8):1429-35.
PMID: 15304051
Platelets from protease-activated receptor 4 (PAR4)-deficient mice are unresponsive to thrombin, and Par4-/- mice have prolonged bleeding times and are protected against thrombosis. However, in addition to its role in...
6.
Coughlin S
Cold Spring Harb Symp Quant Biol
. 2003 Jul;
67:197-208.
PMID: 12858541
No abstract available.
7.
Sambrano G, Weiss E, Zheng Y, Huang W, Coughlin S
Nature
. 2001 Sep;
413(6851):74-8.
PMID: 11544528
Platelets are critical in haemostasis and in arterial thrombosis, which causes heart attacks and other events triggered by abnormal clotting. The coagulation protease thrombin is a potent activator of platelets...
8.
Griffin C, Srinivasan Y, Zheng Y, Huang W, Coughlin S
Science
. 2001 Sep;
293(5535):1666-70.
PMID: 11533492
The coagulation protease thrombin triggers fibrin formation, platelet activation, and other cellular responses at sites of tissue injury. We report a role for PAR1, a protease-activated G protein-coupled receptor for...
9.
Coughlin S
Thromb Haemost
. 2001 Aug;
86(1):298-307.
PMID: 11487018
G protein-coupled protease-activated receptors (PARs) provide one answer to the question of how coagulation factors and other proteases regulate cellular behaviors. In concert with the coagulation cascade, these receptors provide...
10.
Lindner J, Kahn M, Coughlin S, Sambrano G, Schauble E, Bernstein D, et al.
J Immunol
. 2000 Nov;
165(11):6504-10.
PMID: 11086091
Endothelial surface expression of P-selectin and subsequent leukocyte rolling in venules can be induced by mast cell-derived histamine and binding of thrombin to protease-activated receptor-1 (PAR1). We hypothesized that activation...