S O Sharrow
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Explore the profile of S O Sharrow including associated specialties, affiliations and a list of published articles.
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Articles
141
Citations
2958
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Recent Articles
1.
Sharrow S
Curr Protoc Immunol
. 2008 Aug;
Chapter 5:Unit 5.2.
PMID: 18668699
This unit provides several approaches to flow cytometry data analysis. Frequency determinations based on analysis of single-parameter fluorescence histograms and dual-parameter contour plots are presented. Next, steps are described for...
2.
BOSSELUT R, Feigenbaum L, Sharrow S, Singer A
Immunity
. 2001 May;
14(4):483-94.
PMID: 11336693
The present study has assessed the impact of the intracellular domains of CD4 and CD8 on positive selection and lineage direction of MHC class I-restricted thymocytes. Contrary to current presumption,...
3.
Sheard M, Sharrow S, Takahama Y
Scand J Immunol
. 2000 Dec;
52(6):550-4.
PMID: 11119259
Multiple model systems have demonstrated that negatively selected thymocytes can be deleted during the immature CD4(+)CD8(+) CD3(low) stage after high affinity interaction of T-cell receptors (TCRs) with antigen:major histocompatibility complex...
4.
Brugnera E, Bhandoola A, Cibotti R, Yu Q, Guinter T, Yamashita Y, et al.
Immunity
. 2000 Aug;
13(1):59-71.
PMID: 10933395
A central paradigm of T cell development is that CD4+8+ (DP) thymocytes differentiate into CD4+ or CD8+ T cells in response to intrathymic signals that extinguish transcription of the inappropriate...
5.
Cibotti R, Bhandoola A, Guinter T, Sharrow S, Singer A
Mol Cell Biol
. 2000 May;
20(11):3852-9.
PMID: 10805728
T-cell development in the thymus is characterized by changing expression patterns of CD4 and CD8 coreceptor molecules and by changes in CD4 and CD8 gene transcription. In response to T-cell...
6.
Bhandoola A, Cibotti R, Punt J, Granger L, Adams A, Sharrow S, et al.
Immunity
. 1999 Apr;
10(3):301-11.
PMID: 10204486
During positive selection, immature thymocytes commit to either the CD4+ or CD8+ T cell lineage ("commitment") and convert from short-lived thymocytes into long-lived T cells ("rescue"). By formal precursor-progeny analysis,...
7.
Wu W, Punt J, Granger L, Sharrow S, Kearse K
Glycobiology
. 1997 Apr;
7(3):349-56.
PMID: 9147043
Intrathymic maturation of T lymphocytes is characterized by variable expression of O-linked Gal beta 1,3GalNAc glycans reactive with peanut agglutinin (PNA) lectin. Recent studies on human thymocytes show that conversion...
8.
Cibotti R, Punt J, Dash K, Sharrow S, Singer A
Immunity
. 1997 Mar;
6(3):245-55.
PMID: 9075925
Differentiation of immature double positive (DP) CD4+ CD8+ thymocytes into single positive (SP) CD4+ and CD8+ T cells is referred to as positive selection and requires physical contact with thymic...
9.
Punt J, Suzuki H, Granger L, Sharrow S, Singer A
J Exp Med
. 1996 Dec;
184(6):2091-9.
PMID: 8976166
Lineage commitment is a developmental process by which individual CD4+CD8+ (double positive, DP) thymocytes make a decision to differentiate into either CD4+ or CD8+ T cells. However, the molecular event(s)...
10.
Wu W, Harley P, Punt J, Sharrow S, Kearse K
J Exp Med
. 1996 Aug;
184(2):759-64.
PMID: 8760831
Differentiation of most T lymphocytes occurs within the thymus and is characterized by variable expression of CD4/CD8 coreceptor molecules, increased surface density of T cell antigen receptor (TCR) alpha beta...