S O Leung
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Explore the profile of S O Leung including associated specialties, affiliations and a list of published articles.
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21
Citations
116
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Recent Articles
1.
Nolan K, Yun C, Akamatsu Y, Murphy J, Leung S, Beecham E, et al.
Clin Cancer Res
. 2000 Jan;
5(12):3928-41.
PMID: 10632322
Tumor-associated antigens are typically nonimmunogenic in cancer patients, "immune surveillance" having manifestly failed. The fact that most tumor antigens are normal human proteins presents significant obstacles to current cancer immunization...
2.
Leung S, Qu Z, Hansen H, Shih L, Wang J, Losman M, et al.
Clin Cancer Res
. 1999 Nov;
5(10 Suppl):3106s-3117s.
PMID: 10541351
Antibody (Ab) fragments are preferred agents for imaging applications because of their rapid clearance from the blood, thereby providing high tumor:blood ratios within a few hours. Several preclinical studies have...
3.
Losman M, Qu Z, Krishnan I, Wang J, Hansen H, Goldenberg D, et al.
Clin Cancer Res
. 1999 Nov;
5(10 Suppl):3101s-3105s.
PMID: 10541350
Antibody humanization has eliminated or reduced the human antimouse antibody response associated with the administration of murine antibodies. We have successfully humanized three different antibodies: (a) hMN-3 (granulocyte targeting); (b)...
4.
Qu Z, Losman M, Eliassen K, Hansen H, Goldenberg D, Leung S
Clin Cancer Res
. 1999 Nov;
5(10 Suppl):3095s-3100s.
PMID: 10541349
Immu31 is a murine monoclonal antibody (Ab) specific for alpha-fetoprotein (AFP), a tumor-associated marker. The excellent tumor targeting ability of Immu31 has led to the development of a Immu31-based radioimmunodiagnostic...
5.
Krishnan I, Hansen H, Gold D, Goldenberg D, Leung S
Hybridoma
. 1999 Nov;
18(4):325-33.
PMID: 10571262
Mu-9 is a monoclonal antibody (MAb) specific for the CSAp antigen (Ag) expressed by colorectal cancers. By using variable (V)-region-specific primers, the respective VH and VL sequences of Mu-9 were...
6.
Akamatsu Y, Murphy J, Nolan K, Thomas P, Kreitman R, Leung S, et al.
Clin Cancer Res
. 1998 Nov;
4(11):2825-32.
PMID: 9829749
We have engineered an anti-carcinoembryonic antigen (CEA) single-chain immunotoxin derived from humanized anti-CEA antibody (hMN14) and a truncated Pseudomonas exotoxin (PE), PE40. The purified anti-CEA immunotoxin (hMN14(Fv)-PE40) was first measured...
7.
Qu Z, Sharkey R, Hansen H, Shih L, Govindan S, Shen J, et al.
J Immunol Methods
. 1998 Aug;
213(2):131-44.
PMID: 9692846
To improve the efficiency of site-specific conjugation of chelates and drugs to antibodies, and to minimize the incidence of immunoreactivity perturbation to the resultant immunoconjugates, Asn-linked oligosaccharide moieties were designed...
8.
Chimerization of Mu-9: a colon-specific antigen-p antibody reactive with gastrointestinal carcinomas
Krishnan I, Hansen H, Losman M, Goldenberg D, Leung S
Cancer
. 1997 Dec;
80(12 Suppl):2667-74.
PMID: 9406723
Background: Mu-9 is a murine monoclonal antibody that is directed against affinity-purified colon-specific antigen-p (CSAp). CSAp is a tumor-associated antigen that is present in 60% of colorectal carcinomas. Preclinical and...
9.
Losman M, Hansen H, Dworak H, Krishnan I, Qu Z, Shih L, et al.
Cancer
. 1997 Dec;
80(12 Suppl):2660-6.
PMID: 9406722
Background: LL2 is a murine immunoglobulin (Ig)G2a-kappa anti-B-cell monoclonal antibody with proven targeting and therapeutic efficacy in the management of non-Hodgkin's lymphoma (NHL). The authors had previously generated a humanized...
10.
Leung S, Goldenberg D, Dion A, Pellegrini M, Shevitz J, Shih L, et al.
Mol Immunol
. 1995 Dec;
32(17-18):1413-27.
PMID: 8643111
The murine monoclonal antibody, LL2, is a B-cell (CD22)-specific IgG2a which has been demonstrated to be clinically significant in the radioimmunodetection of non-Hodgkin's B-cell lymphoma. The antibody carries a variable...