S N Mitchell
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Explore the profile of S N Mitchell including associated specialties, affiliations and a list of published articles.
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37
Citations
555
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Recent Articles
1.
Witkin J, Mitchell S, Wafford K, Carter G, Gilmour G, Li J, et al.
J Pharmacol Exp Ther
. 2017 Feb;
361(1):68-86.
PMID: 28138040
The ability of the -methyl-d-aspartate receptor antagonist ketamine to alleviate symptoms in patients suffering from treatment-resistant depression (TRD) is well documented. In this paper, we directly compare in vivo biologic...
2.
Witkin J, Monn J, Schoepp D, Li X, Overshiner C, Mitchell S, et al.
J Pharmacol Exp Ther
. 2016 May;
358(1):71-82.
PMID: 27189960
Ketamine is a rapidly acting antidepressant in patients with treatment-resistant depression (TRD). Although the mechanisms underlying these effects are not fully established, inquiry to date has focused on the triggering...
3.
Austin P, Betts M, Broadstock M, ONeill M, Mitchell S, Duty S
Br J Pharmacol
. 2010 Jul;
160(7):1741-53.
PMID: 20649576
Background And Purpose: Increased glutamatergic innervation of the substantia nigra pars reticulata (SNpr) and pars compacta (SNpc) may contribute to the motor deficits and neurodegeneration, respectively, in Parkinson's disease (PD)....
4.
Joseph M, Peters S, Prior A, Mitchell S, Brazell M, Gray J
Neurochem Int
. 2010 May;
16(3):269-73.
PMID: 20504567
Acute nicotine treatment increases catecholamine synthesis selectively in the nucleus accumbens, hypothalamus and hippocampus of the rat. In the hippocampus, but not in the other areas mentioned, or in the...
5.
Chan W, McKinzie D, Bose S, Mitchell S, Witkin J, Thompson R, et al.
Proc Natl Acad Sci U S A
. 2008 Aug;
105(31):10978-83.
PMID: 18678919
Current antipsychotics provide symptomatic relief for patients suffering from schizophrenia and related psychoses; however, their effectiveness is variable and many patients discontinue treatment due to side effects. Although the etiology...
6.
Boot J, Boulet S, CLARK B, Cases-Thomas M, Delhaye L, Diker K, et al.
Bioorg Med Chem Lett
. 2006 Feb;
16(10):2714-8.
PMID: 16497500
A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.
7.
Visanji N, Mitchell S, ONeill M, Duty S
Neuropharmacology
. 2005 Sep;
50(1):36-46.
PMID: 16153666
Whilst local intrastriatal infusion of nicotine consistently elicits striatal dopamine release, systemic administration often fails to do so. Since chronic nicotine administration is known to result in desensitisation-induced upregulation of...
8.
Storey J, Robertson D, Beattie J, Reid I, Mitchell S, Balfour D
Behav Brain Res
. 2005 Sep;
166(2):220-9.
PMID: 16150498
Increased psychophysiological resistance to chronic stress has been related to increased 5-HT release in the dorsal hippocampus. This study investigated the changes in 5-HT release and turnover in the hippocampus...
9.
Boot J, Brace G, Delatour C, Dezutter N, Fairhurst J, Findlay J, et al.
Bioorg Med Chem Lett
. 2004 Sep;
14(21):5395-9.
PMID: 15454233
A series of benzothienyloxy propylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.
10.
Mitchell S, Greenslade R, Cooper J
Eur J Pharmacol
. 2001 Dec;
432(1):19-27.
PMID: 11734183
The stimulation of terminal 5-HT(1B/1D) autoreceptors limits the effects of selective serotonin reuptake inhibitors on extracellular levels of 5-hydroxytryptamine (5-HT, serotonin) in vivo. Microdialysis studies show that acute oral administration...