S M Mikulski
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Explore the profile of S M Mikulski including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
513
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Recent Articles
1.
Halicka D, Pozarowski P, Ita M, Ardelt W, Mikulski S, Shogen K, et al.
Int J Oncol
. 2002 Nov;
21(6):1245-50.
PMID: 12429974
Onconase (Onc) is an amphibian ribonuclease of the pancreatic RNase family that is cytostatic and cytotoxic to several tumor lines. It also shows anti-tumor activity in mouse tumor models and...
2.
Vogelzang N, Aklilu M, Stadler W, Dumas M, Mikulski S
Invest New Drugs
. 2001 Sep;
19(3):255-60.
PMID: 11561684
Ranpirnase (Onconase) is the first ribonuclease to enter cancer clinical trials. In prior phase II trials, responses were seen in mesothelioma and other solid tumors. This phase II trial tested...
3.
Newton D, Hansen H, Mikulski S, Goldenberg D, Rybak S
Blood
. 2001 Jan;
97(2):528-35.
PMID: 11154233
LL2, an anti-CD22 monoclonal antibody against B-cell lymphoma, was covalently linked to the amphibian ribonuclease, onconase, a member of the pancreatic RNase A superfamily. LL2 increased in vitro potency (10...
4.
Halicka H, Murakami T, Papageorgio C, Mittelman A, Mikulski S, Shogen K, et al.
Cell Prolif
. 2000 Dec;
33(6):407-17.
PMID: 11101012
Onconase (Onc) is a ribonuclease from amphibian oocytes that is cytostatic and cytotoxic to many tumour lines. It shows in vivo antitumour activity in mouse tumour models and is currently...
5.
Lee I, Lee Y, Mikulski S, Lee J, Shogen K
Anticancer Res
. 2000 May;
20(2A):1037-40.
PMID: 10810394
The RNase-like onconase, isolated from amphibian oocytes, showed increases in median tumor pO2 in solid tumors (1). This led us to consider if onconase could decrease cellular O2 consumption (QO2)...
6.
Lee I, Lee Y, Mikulski S, Lee J, Covone K, Shogen K
J Surg Oncol
. 2000 Mar;
73(3):164-71.
PMID: 10738271
Background And Objectives: The effects of Onconase (Onc) on the tumor growth in vitro and in vivo were examined. Because elevated tumor interstitial fluid pressure (TIFP) is one of the...
7.
Vasandani V, Castelli J, Hott J, Saxena S, Mikulski S, Youle R
J Interferon Cytokine Res
. 1999 Jul;
19(5):447-54.
PMID: 10386856
Interferons (IFN) are biologic agents involved in the antiviral response and the inhibition of tumor growth. Biochemical pathways of IFN action include the double-stranded RNA-activated oligoadenylate synthetase, RNase L, and...
8.
Smith M, Newton D, Mikulski S, Rybak S
Exp Cell Res
. 1999 Feb;
247(1):220-32.
PMID: 10047464
Microinjection of Onconase or RNase A into NIH/3T3 cells was used to study the intracellular actions of these two proteins. Onconase preferentially killed actively growing cells in both microinjection and...
9.
Mikulski S, Viera A, Deptala A, Darzynkiewicz Z
Int J Oncol
. 1998 Sep;
13(4):633-44.
PMID: 9735389
In proliferating cells the turnover rate of proteins responsible for regulation of the cell cycle progression, namely cyclins and inhibitors of the cyclin-dependent kinases (CDKs) and phosphatases, is rapid and...
10.
Juan G, Ardelt B, Li X, Mikulski S, Shogen K, Ardelt W, et al.
Leukemia
. 1998 Aug;
12(8):1241-8.
PMID: 9697879
Onconase is a 12 kDa protein homologous to pancreatic RNase A isolated from amphibian oocytes which shows cytostatic and cytotoxic activity in vitro, inhibits growth of tumors in mice and...