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Z Darzynkiewicz

Explore the profile of Z Darzynkiewicz including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 404
Citations 5792
Followers 0
Related Specialties
Cell Biology
Oncology
Biochemistry
Top 10 Co-Authors
F Traganos
M R Melamed
W Gorczyca
X Li
G Juan
E Bedner
L Staiano-Coico
J Kapuscinski
J Gong
T Sharpless
Published In
Exp Cell Res
Cancer Res
Cytometry
Int J Oncol
J Histochem Cytochem
Affiliations
Soon will be listed here.
Recent Articles
1.
New insights into cell cycle and DNA damage response machineries through high-resolution AMICO quantitative imaging cytometry
Tarnok A, Darzynkiewicz Z
Cell Prolif . 2013 Aug; 46(5):497-500. PMID: 23952744
Objective: Progress in biology and medicine research is being driven by development of new instrumentation and associated methodologies which open analytical capabilities that expand understanding of complexity of biological systems....
2.
Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis
Berniak K, Rybak P, Bernas T, Zarebski M, Biela E, Zhao H, et al.
Cytometry A . 2013 Jul; 83(10):913-24. PMID: 23846844
A method of quantitative analysis of spatial (3D) relationship between discrete nuclear events detected by confocal microscopy is described and applied in analysis of a dependence between sites of DNA...
3.
Cytometry of apoptosis. Historical perspective and new advances
Wlodkowic D, Skommer J, Darzynkiewicz Z
Exp Oncol . 2012 Oct; 34(3):255-62. PMID: 23070010
Characteristic changes in cell morphology paralleled by the appearance of a multitude of molecular and biochemical markers occur during apoptosis. These changes vary depending on the cell type, mechanism of...
4.
DNA strand breaks occurring during apoptosis - their early insitu detection by the terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors
Gorczyca W, Bruno S, Darzynkiewicz R, Gong J, Darzynkiewicz Z
Int J Oncol . 2011 May; 1(6):639-48. PMID: 21584593
The appearance of DNA strand breaks during apoptosis was detected in individual cells, in relation to the cell cycle phase, by a novel assay based on labeling 3'-OH termini with...
5.
The protein-kinase-C inhibitor h7 blocks normal human lymphocyte stimulation and induces apoptosis of both normal lymphocytes and leukemia molt-4 cells
Traganos F, Knuttihotz J, Hotz M, Gorczyca W, Ardelt B, Darzynkiewicz Z
Int J Oncol . 2011 May; 2(1):47-59. PMID: 21573514
The isoquinoline sulfonamide (H7) is an inhibitor of protein kinase C (PKC) that also inhibits the activity of cyclic nucleotide-dependent protein kinases. The effect of H7 on mitogen stimulation (G0...
6.
Expression of cyclins-B and cyclins-e in individual molt-4 cells and in stimulated human-lymphocytes during their progression through the cell-cycle
Gong J, Traganos F, Darzynkiewicz Z
Int J Oncol . 2011 May; 3(6):1037-42. PMID: 21573469
Cyclins B (B1) and E, integral components of the cell cycle drive machinery consisting of p34cdc2 and p33cdk2 cyclin-dependent kinases and their regulatory kinases and phosphatases, were detected in human...
7.
Different rates of degradation of the proliferation-associated nuclear and nucleolar antigens during apoptosis of hl-60 cells induced by DNA topoisomerase inhibitors
Gorczyca W, Ardelt B, Darzynkiewicz Z
Int J Oncol . 2011 May; 3(4):627-34. PMID: 21573410
One of the early events of apoptosis is proteolysis. The enzyme(s) involved in this event appear to be the serine protease(s), inasmuch as the reversible or irreversible inhibitors of serine...
8.
Effects of linoleic-Acid on mammary-tumor cell-proliferation are associated with changes in p53 protein expression
Tillotson J, Darzynkiewicz Z, Cohen L, Ronai Z
Int J Oncol . 2011 May; 3(1):81-7. PMID: 21573330
A rat mammary tumor cell line maintained in low serum (1%) medium exhibited a slower growth rate, altered cell cycle distribution, decreased DNA synthesis, and increased immunoprecipitable p53, when compared...
9.
Detection of 5-bromo-2-deoxyuridine incorporated into DNA by labeling strand breaks induced by photolysis (sbip)
Li X, Traganos F, Melamed M, Darzynkiewicz Z
Int J Oncol . 2011 May; 4(6):1157-61. PMID: 21567032
A novel method to identify DNA replicating cells is described. In this method DNA strand breaks at sites of incorporation of 5-bromo-2-deoxyuridine (BrdUrd) are induced by photolysis and labeled with...
10.
Use of the cyclin e restriction point to map cell arrest in g(1)-induced by N-butyrate, cycloheximide, staurosporine, lovastatin, mimosine and quercetin
Gong J, Traganos F, Darzynkiewicz Z
Int J Oncol . 2011 May; 4(4):803-8. PMID: 21566985
Cyclin E, a member of the G1 cyclin family, is an integral component of the complex machinery of the cell cycle. This protein is synthesized late in the G1 phase...