S L Alper
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Explore the profile of S L Alper including associated specialties, affiliations and a list of published articles.
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Articles
124
Citations
3810
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Recent Articles
1.
Alper S
Curr Top Membr
. 2017 Jul;
79:97-134.
PMID: 28728825
Mutations in the genes encoding the mechanosensitive cation channels PIEZO1 and PIEZO2 are responsible for multiple hereditary human diseases. Loss-of-function mutations in the human PIEZO1 gene cause autosomal recessive congenital...
2.
Heneghan J, Vandorpe D, Shmukler B, Giovinazzo J, Giovinnazo J, Raper J, et al.
Am J Physiol Cell Physiol
. 2015 Jun;
309(5):C332-47.
PMID: 26108665
The potent trypanolytic properties of human apolipoprotein L1 (APOL1) can be neutralized by the trypanosome variant surface antigen gene product known as serum resistance-associated protein. However, two common APOL1 haplotypes...
3.
4.
Haller C, Alper S
Cytotechnology
. 2012 Feb;
17(2):71-82.
PMID: 22358463
We have evaluated transient transfection of MDCK cells by the DEAE-dextran/chloroquine method as a rapid method for study of heterologous plasma membrane protein polarity. Transiently transfected cells reseeded onto permeable...
5.
Belenky M, Sollars P, Mount D, Alper S, Yarom Y, Pickard G
Neuroscience
. 2009 Nov;
165(4):1519-37.
PMID: 19932740
The suprachiasmatic nucleus (SCN) is a circadian oscillator and biological clock. Cell-to-cell communication is important for synchronization among SCN neuronal oscillators and the great majority of SCN neurons use GABA...
6.
Stewart A, Yamamoto A, Nakakuki M, Kondo T, Alper S, Ishiguro H
Am J Physiol Gastrointest Liver Physiol
. 2009 Apr;
296(6):G1307-17.
PMID: 19342507
Pancreatic ductal epithelium produces a HCO(3)(-)-rich fluid. HCO(3)(-) transport across ductal apical membranes has been proposed to be mediated by both SLC26-mediated Cl(-)/HCO(3)(-) exchange and CFTR-mediated HCO(3)(-) conductance, with proportional...
7.
Stewart A, Kurschat C, Vaughan-Jones R, Shmukler B, Alper S
J Physiol
. 2007 Aug;
584(Pt 1):59-73.
PMID: 17690150
The widely expressed anion exchanger polypeptide AE2/SLC4A2 is acutely inhibited by acidic intracellular (pH(i)), by acidic extracellular pH (pH(o)), and by the calmodulin inhibitor, calmidazolium, whereas it is acutely activated...
8.
Stewart A, Kurschat C, Alper S
Pflugers Arch
. 2007 May;
454(3):373-84.
PMID: 17492309
The ubiquitous AE2/SLC4A2 anion exchanger is acutely and independently regulated by intracellular (pH(i)) and extracellular pH (pH(o)), whereas the closely related AE1/SLC4A1 of the red cell and renal intercalated cell...
9.
Stewart A, Kurschat C, Burns D, Banger N, Vaughan-Jones R, Alper S
Am J Physiol Cell Physiol
. 2006 Sep;
292(2):C909-18.
PMID: 17005605
Activity of the AE2/SLC4A2 anion exchanger is modulated acutely by pH, influencing the transporter's role in regulation of intracellular pH (pH(i)) and epithelial solute transport. In Xenopus oocytes, heterologous AE2-mediated...
10.
Brugnara C, De Franceschi L, Bennekou P, Alper S, Christophersen P
Drug News Perspect
. 2003 Jun;
14(4):208-20.
PMID: 12819792
Sickle cell anemia is a genetic disorder characterized by mutant hemoglobin (Hb) polymerization and resultant cell deformation (sickling) under conditions of reduced oxygen tension. The disease is caused by mutation...