S Kaye Spratt
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Explore the profile of S Kaye Spratt including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
1038
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0
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Recent Articles
1.
Figley S, Liu Y, Karadimas S, Satkunendrarajah K, Fettes P, Spratt S, et al.
PLoS One
. 2014 May;
9(5):e96137.
PMID: 24846143
Following spinal cord injury (SCI) there are drastic changes that occur in the spinal microvasculature, including ischemia, hemorrhage, endothelial cell death and blood-spinal cord barrier disruption. Vascular endothelial growth factor-A...
2.
Tebas P, Stein D, Tang W, Frank I, Wang S, Lee G, et al.
N Engl J Med
. 2014 Mar;
370(10):901-10.
PMID: 24597865
Background: CCR5 is the major coreceptor for human immunodeficiency virus (HIV). We investigated whether site-specific modification of the gene ("gene editing")--in this case, the infusion of autologous CD4 T cells...
3.
Maier D, Brennan A, Jiang S, Binder-Scholl G, Lee G, Plesa G, et al.
Hum Gene Ther
. 2013 Jan;
24(3):245-58.
PMID: 23360514
Since HIV requires CD4 and a co-receptor, most commonly C-C chemokine receptor 5 (CCR5), for cellular entry, targeting CCR5 expression is an attractive approach for therapy of HIV infection. Treatment...
4.
Siddiq I, Park E, Liu E, Spratt S, Surosky R, Lee G, et al.
J Neurotrauma
. 2012 Sep;
29(17):2647-59.
PMID: 23016562
Vascular endothelial growth factor (VEGF) plays a role in angiogenesis and has been shown to be neuroprotective following central nervous system trauma. In the present study we evaluated the pro-angiogenic...
5.
Zhang H, Liu D, Huang Y, Schmidt S, Hickey R, Guschin D, et al.
Mol Ther
. 2012 Jul;
20(8):1508-15.
PMID: 22828502
Selective inhibition of disease-related proteins underpins the majority of successful drug-target interactions. However, development of effective antagonists is often hampered by targets that are not druggable using conventional approaches. Here,...
6.
DOnofrio P, Thayapararajah M, Lysko M, Magharious M, Spratt S, Lee G, et al.
J Neurotrauma
. 2011 Sep;
28(9):1863-79.
PMID: 21902538
Recent studies have identified anti-apoptotic functions for vascular endothelial growth factor (VEGF) in the central nervous system (CNS). However, VEGF therapy has been hampered by a tendency to promote vascular...
7.
Kliem M, Heeke B, Franz C, Radovitskiy I, Raore B, Barrow E, et al.
Amyotroph Lateral Scler
. 2011 Aug;
12(5):331-9.
PMID: 21864053
Amyotrophic lateral sclerosis (ALS) is characterized by motor neuron loss leading to paralysis and death. Vascular endothelial growth factor (VEGF) has angiogenic, neurotrophic, and neuroprotective properties, and has preserved neuromuscular...
8.
Pawson E, Duran-Jimenez B, Surosky R, Brooke H, Spratt S, Tomlinson D, et al.
Diabetes
. 2009 Nov;
59(2):509-18.
PMID: 19934008
Objective: The objectives of the study were to evaluate retrograde axonal transport of vascular endothelial growth factor A (VEGF-A) protein to sensory neurons after intramuscular administration of an engineered zinc...
9.
An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury
Liu Y, Figley S, Spratt S, Lee G, Ando D, Surosky R, et al.
Neurobiol Dis
. 2009 Nov;
37(2):384-93.
PMID: 19879362
Spinal cord injury (SCI) leads to local vascular disruption and progressive ischemia, which contribute to secondary degeneration. Enhancing angiogenesis through the induction of vascular endothelial growth factor (VEGF)-A expression therefore...
10.
Yokoi K, Kachi S, Zhang H, Gregory P, Spratt S, Samulski R, et al.
Invest Ophthalmol Vis Sci
. 2007 Jun;
48(7):3324-8.
PMID: 17591905
Purpose: Self-complementary AAV (scAAV) vectors have been developed to circumvent rate-limiting second-strand synthesis in single-stranded AAV vector genomes and to facilitate robust transgene expression at a minimal dose. In this...