H Steve Zhang
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Explore the profile of H Steve Zhang including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
2786
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0
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Recent Articles
1.
Persistent repression of tau in the brain using engineered zinc finger protein transcription factors
Wegmann S, DeVos S, Zeitler B, Marlen K, Bennett R, Perez-Rando M, et al.
Sci Adv
. 2021 Mar;
7(12).
PMID: 33741591
Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we introduce a novel translational approach to lower expression of the tau gene at...
2.
Zeitler B, Froelich S, Marlen K, Shivak D, Yu Q, Li D, et al.
Nat Med
. 2019 Jul;
25(7):1131-1142.
PMID: 31263285
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since...
3.
Heller E, Cates H, Pena C, Sun H, Shao N, Feng J, et al.
Nat Neurosci
. 2014 Oct;
17(12):1720-7.
PMID: 25347353
Chronic exposure to drugs of abuse or stress regulates transcription factors, chromatin-modifying enzymes and histone post-translational modifications in discrete brain regions. Given the promiscuity of the enzymes involved, it has...
4.
Sanders L, Laganiere J, Cooper O, Mak S, Vu B, Huang Y, et al.
Neurobiol Dis
. 2013 Oct;
62:381-6.
PMID: 24148854
Parkinson's disease associated mutations in leucine rich repeat kinase 2 (LRRK2) impair mitochondrial function and increase the vulnerability of induced pluripotent stem cell (iPSC)-derived neural cells from patients to oxidative...
5.
Zhang H, Liu D, Huang Y, Schmidt S, Hickey R, Guschin D, et al.
Mol Ther
. 2012 Jul;
20(8):1508-15.
PMID: 22828502
Selective inhibition of disease-related proteins underpins the majority of successful drug-target interactions. However, development of effective antagonists is often hampered by targets that are not druggable using conventional approaches. Here,...
6.
Zhang H, Kim E, Lee S, Ahn I, Jang J
J Virol Methods
. 2011 Oct;
179(1):276-80.
PMID: 22015677
Recombinant adeno-associated virus (AAV) vectors can be engineered to carry genetic material encoding therapeutic gene products that have demonstrated significant clinical promise. These viral vectors are typically produced in mammalian...
7.
Soldner F, Laganiere J, Cheng A, Hockemeyer D, Gao Q, Alagappan R, et al.
Cell
. 2011 Jul;
146(2):318-31.
PMID: 21757228
Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising source for cell replacement therapies....
8.
Miller J, Tan S, Qiao G, Barlow K, Wang J, Xia D, et al.
Nat Biotechnol
. 2010 Dec;
29(2):143-8.
PMID: 21179091
Nucleases that cleave unique genomic sequences in living cells can be used for targeted gene editing and mutagenesis. Here we develop a strategy for generating such reagents based on transcription...
9.
Laganiere J, Kells A, Lai J, Guschin D, Paschon D, Meng X, et al.
J Neurosci
. 2010 Dec;
30(49):16469-74.
PMID: 21147986
Loss of dopaminergic neurons is primarily responsible for the onset and progression of Parkinson's disease (PD); thus, neuroprotective and/or neuroregenerative strategies remain critical to the treatment of this increasingly prevalent...
10.
Urnov F, Rebar E, Holmes M, Zhang H, Gregory P
Nat Rev Genet
. 2010 Aug;
11(9):636-46.
PMID: 20717154
Reverse genetics in model organisms such as Drosophila melanogaster, Arabidopsis thaliana, zebrafish and rats, efficient genome engineering in human embryonic stem and induced pluripotent stem cells, targeted integration in crop...