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S Gandy

Explore the profile of S Gandy including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 71
Citations 1674
Followers 0
Related Specialties
Neurology
Molecular Biology
Psychiatry
Top 10 Co-Authors
P Greengard
N R Relkin
R N Martins
M E Ehrlich
M Seeger
H Xu
D Sweeney
G K Gouras
S Petanceska
J W Steele
Published In
Mol Psychiatry
Neurobiol Aging
J Biol Chem
Proc Natl Acad Sci U S A
Ann N Y Acad Sci
Affiliations
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Recent Articles
1.
Experimental Assessment of Two Non-Contrast MRI Sequences Used for Computational Fluid Dynamics: Investigation of Consistency Between Techniques
MacDonald C, Hellmuth R, Priba L, Murphy E, Gandy S, Matthew S, et al.
Cardiovasc Eng Technol . 2020 Jul; 11(4):416-430. PMID: 32613600
Purpose: Recent studies have noted a degree of variance between the geometries segmented by different groups from 3D medical images that are used in computational fluid dynamics (CFD) simulations of...
2.
Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents
Katsel P, Roussos P, Beeri M, Gama-Sosa M, Gandy S, Khan S, et al.
PLoS One . 2018 Nov; 13(11):e0206547. PMID: 30383799
A large body of literature links risk of cognitive decline, mild cognitive impairment (MCI) and dementia with Type 2 Diabetes (T2D) or pre-diabetes. Accumulating evidence implicates a close relationship between...
3.
Antemortem biomarker support for a diagnosis of clinically probable chronic traumatic encephalopathy
Pullman M, Dickstein D, DeKosky S, Gandy S
Mol Psychiatry . 2017 Jan; 22(5):638-639. PMID: 28070125
No abstract available.
4.
Cerebral [ F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy
Dickstein D, Pullman M, Fernandez C, Short J, Kostakoglu L, Knesaurek K, et al.
Transl Psychiatry . 2016 Sep; 6(9):e900. PMID: 27676441
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disorder most commonly associated with repetitive traumatic brain injury (TBI) and characterized by the presence of neurofibrillary tangles of tau protein, known as...
5.
Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology
Readhead B, Haure-Mirande J, Zhang B, Haroutunian V, Gandy S, Schadt E, et al.
Mol Psychiatry . 2016 Jan; 21(8):1153-4. PMID: 26782051
No abstract available.
6.
Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology
Readhead B, Haure-Mirande J, Zhang B, Haroutunian V, Gandy S, Schadt E, et al.
Mol Psychiatry . 2015 Nov; 21(8):1099-111. PMID: 26552589
Identification and characterization of molecular mechanisms that connect genetic risk factors to initiation and evolution of disease pathophysiology represent major goals and opportunities for improving therapeutic and diagnostic outcomes in...
7.
Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ
Knight E, Williams H, Stevens A, Kim S, Kottwitz J, Morant A, et al.
Mol Psychiatry . 2014 Oct; 20(1):109-17. PMID: 25349165
Certain mutant Alzheimer's amyloid-β (Aβ) peptides (that is, Dutch mutant APP(E693Q)) form complexes with gangliosides (GAβ). These mutant Aβ peptides may also undergo accelerated aggregation and accumulation upon exposure to...
8.
Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury
Mitsis E, Riggio S, Kostakoglu L, Dickstein D, Machac J, Delman B, et al.
Transl Psychiatry . 2014 Sep; 4:e441. PMID: 25226550
Single, severe traumatic brain injury (TBI) which elevates CNS amyloid, increases the risk of Alzheimer's disease (AD); while repetitive concussive and subconcussive events as observed in athletes and military personnel,...
9.
Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse
Kim S, Steele J, Lee S, Clemenson G, Carter T, Treuner K, et al.
Mol Psychiatry . 2014 Aug; 19(11):1235-42. PMID: 25113378
Proneurogenic compounds have recently shown promise in some mouse models of Alzheimer's pathology. Antagonists at Group II metabotropic glutamate receptors (Group II mGluR: mGlu2, mGlu3) are reported to stimulate neurogenesis....
10.
Immunomodulation and AD--down but not out
Knight E, Gandy S
J Clin Immunol . 2014 May; 34 Suppl 1:S70-3. PMID: 24781637
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most common cause of dementia in the elderly. Interventions that remove existing fibrillar and oligomeric amyloid-β (Aβ) are believed...