S C Manolagas
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Explore the profile of S C Manolagas including associated specialties, affiliations and a list of published articles.
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119
Citations
7216
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Recent Articles
1.
Jia D, OBrien C, Stewart S, Manolagas S, Weinstein R
Endocrinology
. 2006 Aug;
147(12):5592-9.
PMID: 16935844
Glucocorticoid administration to mice results in a rapid loss of bone mineral density due to an imbalance in osteoblast and osteoclast numbers. Whereas excess glucocorticoids reduce both osteoblast and osteoclast...
2.
Almeida M, Han L, OBrien C, Kousteni S, Manolagas S
Endocrinology
. 2005 Dec;
147(4):1986-96.
PMID: 16384865
Elucidation of kinase-initiated routes by which the estrogen receptors alpha and beta (ERalpha and ERbeta) control gene transcription, along with evidence of distinct biologic outcomes in response to ligands that...
3.
Bellido T, Ali A, Gubrij I, Plotkin L, Fu Q, OBrien C, et al.
Endocrinology
. 2005 Aug;
146(11):4577-83.
PMID: 16081646
Both chronic excess of PTH, as in hyperparathyroidism, and intermittent elevation of PTH (by daily injections) increase the number of osteoblasts; albeit, the former is associated with bone catabolism and...
4.
Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs
Plotkin L, Mathov I, Aguirre J, Parfitt A, Manolagas S, Bellido T
Am J Physiol Cell Physiol
. 2005 May;
289(3):C633-43.
PMID: 15872009
Osteocytes, former osteoblasts entombed in the bone matrix, form an extensive cell communication network that is thought to detect microdamage and mechanical strains and to transmit signals leading to repair...
5.
Kousteni S, Chen J, Bellido T, Han L, Ali A, OBrien C, et al.
Science
. 2002 Oct;
298(5594):843-6.
PMID: 12399595
We show that sex steroids protect the adult murine skeleton through a mechanism that is distinct from that used to preserve the mass and function of reproductive organs. The classical...
6.
Manolagas S, Kousteni S, Jilka R
Recent Prog Horm Res
. 2002 May;
57:385-409.
PMID: 12017554
The adult skeleton is periodically remodeled by temporary anatomic structures that comprise juxtaposed osteoclast and osteoblast teams and replace old bone with new. Estrogens and androgens slow the rate of...
7.
OBrien C, Kern B, Gubrij I, Karsenty G, Manolagas S
Bone
. 2002 Mar;
30(3):453-62.
PMID: 11882458
The rates of osteoblast and osteoclast formation are tightly balanced, possibly due to the requirement of mesenchymal osteoblast progenitors for osteoclastogenesis. Osteoblast differentiation requires the transcription factor Cbfa1, whereas osteoclastogenesis...
8.
COKER J, Abe E, Jilka R, Manolagas S
Endocrinology
. 2001 Dec;
143(1):74-83.
PMID: 11751595
Using primary murine bone marrow cell cultures, we demonstrate that inhibin suppresses osteoblastogenesis and osteoclastogenesis. In contrast, activin supports osteoblast formation (by alkaline phosphatase-positive and mineralized colony formation); and activin...
9.
Mancino A, Klimberg V, Yamamoto M, Manolagas S, Abe E
J Surg Res
. 2001 Aug;
100(1):18-24.
PMID: 11516200
Background: Breast cancer metastasis to bone causes resorption of the mineralized matrix by osteoclasts. Macrophage colony stimulating factor (M-CSF)and receptor activator of the NF-kappaB ligand (RANKL) are produced by stromal...
10.
Manolagas S, Kousteni S
Endocrinology
. 2001 May;
142(6):2200-4.
PMID: 11356663
No abstract available.