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S C Bunnell

Explore the profile of S C Bunnell including associated specialties, affiliations and a list of published articles. Areas
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Articles 10
Citations 771
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Recent Articles
1.
Bunnell S, Kapoor V, Trible R, Zhang W, Samelson L
Immunity . 2001 Apr; 14(3):315-29. PMID: 11290340
T cell activation induces functional changes in cell shape and cytoskeletal architecture. To facilitate the collection of dynamic, high-resolution images of activated T cells, we plated T cells on coverslips...
2.
Samelson L, Bunnell S, Trible R, Yamazaki T, Zhang W
Cold Spring Harb Symp Quant Biol . 2001 Mar; 64:259-63. PMID: 11232294
No abstract available.
3.
Shan X, Czar M, Bunnell S, Liu P, Liu Y, Schwartzberg P, et al.
Mol Cell Biol . 2000 Aug; 20(18):6945-57. PMID: 10958690
Pleckstrin homology (PH) domain binding to D3-phosphorylated phosphatidylinositides (PI) provides a reversible means of recruiting proteins to the plasma membrane, with the resultant change in subcellular localization playing a key...
4.
Bunnell S, Diehn M, Yaffe M, Findell P, Cantley L, Berg L
J Biol Chem . 2000 Jan; 275(3):2219-30. PMID: 10636929
Itk, a Tec family tyrosine kinase, acts downstream of Lck and phosphatidylinositol 3'-kinase to facilitate T cell receptor (TCR)-dependent calcium influxes and increases in extracellular-regulated kinase activity. Here we demonstrate...
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Liu K, Bunnell S, Gurniak C, Berg L
J Exp Med . 1998 Jun; 187(10):1721-7. PMID: 9584150
Itk, a Tec family tyrosine kinase, plays an important but as yet undefined role in T cell receptor (TCR) signaling. Here we show that T cells from Itk-deficient mice have...
7.
Heyeck S, Wilcox H, Bunnell S, Berg L
J Biol Chem . 1997 Oct; 272(40):25401-8. PMID: 9312162
The Tec family tyrosine kinase Itk has been implicated in T cell receptor (TCR) signaling, yet its precise role and mechanism of activation remain undefined. To investigate these issues, we...
8.
Andreotti A, Bunnell S, Feng S, Berg L, Schreiber S
Nature . 1997 Jan; 385(6611):93-7. PMID: 8985255
The T-cell-specific tyrosine kinase Itk is a member of the Tec family of non-receptor tyrosine kinases, and is required for signalling through the T-cell antigen receptor (TCR). The role of...
9.
Bunnell S, HENRY P, Kolluri R, Kirchhausen T, Rickles R, Berg L
J Biol Chem . 1996 Oct; 271(41):25646-56. PMID: 8810341
The tyrosine kinase Itk/Tsk is a T cell specific analog of Btk, the tyrosine kinase defective in the human immunodeficiency X-linked agammaglobulinemia and in xid mice. T lymphocytes from Itk-deficient...
10.
Raab M, Cai Y, Bunnell S, Heyeck S, Berg L, Rudd C
Proc Natl Acad Sci U S A . 1995 Sep; 92(19):8891-5. PMID: 7568038
T-cell activation requires cooperative signals generated by the T-cell antigen receptor zeta-chain complex (TCR zeta-CD3) and the costimulatory antigen CD28. CD28 interacts with three intracellular proteins-phosphatidylinositol 3-kinase (PI 3-kinase), T...