Ryuya Yamanaka
Overview
Explore the profile of Ryuya Yamanaka including associated specialties, affiliations and a list of published articles.
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88
Citations
1327
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Recent Articles
1.
Osako R, Hayano A, Kawaguchi A, Yamanaka R
J Neurooncol
. 2025 Feb;
172(1):175.
PMID: 39913048
No abstract available.
2.
Osako R, Hayano A, Kawaguchi A, Yamanaka R
J Neurooncol
. 2024 Dec;
172(1):163-173.
PMID: 39636551
Purpose: Methotrexate is one of the most essential single agents in patients with primary central nervous system lymphoma (PCNSL). However, 25-50% result in relapse with a poor prognosis. Therefore, studies...
3.
Takashima Y, Hamano M, Yoshii K, Hayano A, Fukai J, Iwadate Y, et al.
Int J Clin Oncol
. 2023 Jan;
28(3):468-481.
PMID: 36607476
Purpose: Here, we investigated expression modules reflecting the reciprocal expression of the cancer microenvironment and immune response-related genes associated with poor prognosis in primary central nervous system lymphoma (PCNSL). Methods:...
4.
Takashima Y, Kawaguchi A, Fukai J, Iwadate Y, Kajiwara K, Hondoh H, et al.
PLoS One
. 2021 Jun;
16(6):e0251272.
PMID: 34166375
Dysregulation of cell morphology and cell-cell interaction results in cancer cell growth, migration, invasion, and metastasis. Besides, a balance between the extracellular matrix (ECM) and matrix metalloprotease (MMP) is required...
5.
Takashima Y, Hamano M, Fukai J, Iwadate Y, Kajiwara K, Kobayashi T, et al.
Sci Rep
. 2020 May;
10(1):8435.
PMID: 32439996
Primary central nervous system lymphoma (PCNSL) is a brain malignant non-Hodgkin's B-cell lymphoma. The standard treatments are high-dose methotrexate (MTX)-based chemotherapies and deferred whole brain radiotherapy. However, MTX resistance-dependent global...
6.
Takashima Y, Hayano A, Yamanaka R
Clin Cancer Res
. 2020 Feb;
26(11):2754-2766.
PMID: 32108030
Purpose: Metabolome analysis is an emerging method that provides insight into intracellular and physiologic responses. Methotrexate (MTX) is an antifolate that suppresses DNA syntheses by inhibiting dihydrofolate reductase. High-dose methotrexate...
7.
Takashima Y, Kawaguchi A, Iwadate Y, Hondoh H, Fukai J, Kajiwara K, et al.
PLoS One
. 2020 Feb;
15(2):e0229577.
PMID: 32101576
MicroRNAs (miRNAs) inhibit protein function by silencing the translation of target mRNAs. However, in primary central nervous system lymphoma (PCNSL), the expression and functions of miRNAs are inadequately known. Here,...
8.
Takashima Y, Kawaguchi A, Yamanaka R
Cells
. 2019 Oct;
8(11).
PMID: 31653034
Multivariable analyses of global expression profiling are valid indicators of the prognosis of various diseases including brain cancers. To identify the candidates for markers of prognosis of glioblastoma, we performed...
9.
Takashima Y, Yoshimura T, Kano Y, Hayano A, Hondoh H, Ikenaka K, et al.
BMC Cancer
. 2019 Sep;
19(1):910.
PMID: 31510952
Background: Oligosaccharides of glycoprotein, particularly negatively-charged sialylated N-glycans, on the surface of lymphomas play important roles in cell-cell interactions and bind immunoglobulin-like lectins, causing inflammatory responses and bioregulation. However, their...
10.
Takashima Y, Kawaguchi A, Sato R, Yoshida K, Hayano A, Homma J, et al.
Sci Rep
. 2019 Jul;
9(1):10004.
PMID: 31292525
In current molecular medicine, next-generation sequencing (NGS) for transcript variant detection and multivariable analyses are valid methods for evaluating gene expression, cancer mechanisms, and prognoses of patients. We conducted RNA-sequencing...