Ryu-Suke Nozawa
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Explore the profile of Ryu-Suke Nozawa including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Nozawa R, Yamamoto T, Takahashi M, Tachiwana H, Maruyama R, Hirota T, et al.
Cancer Sci
. 2020 Jun;
111(9):3155-3163.
PMID: 32594560
The eukaryotic nucleus is not a homogenous single-spaced but a highly compartmentalized organelle, partitioned by various types of membraneless structures, including nucleoli, PML bodies, paraspeckles, DNA damage foci and RNA...
12.
Yoshizawa T, Nozawa R, Jia T, Saio T, Mori E
Biophys Rev
. 2020 Mar;
12(2):519-539.
PMID: 32189162
Progress in development of biophysical analytic approaches has recently crossed paths with macromolecule condensates in cells. These cell condensates, typically termed liquid-like droplets, are formed by liquid-liquid phase separation (LLPS)....
13.
Nozawa R, Gilbert N
Trends Cell Biol
. 2019 Jan;
29(3):201-211.
PMID: 30630665
A significant amount of RNA is present in the nucleus of mammalian cells but only a small proportion of it is destined for the cytoplasm and subsequent translation, leaving much...
14.
Buckle A, Nozawa R, Kleinjan D, Gilbert N
Hum Mol Genet
. 2018 Jul;
27(19):3434-3448.
PMID: 30007277
Complex diseases, such as diabetes, are influenced by comprehensive transcriptional networks. Genome-wide association studies have revealed that variants located in regulatory elements for pancreatic transcription factors are linked to diabetes,...
15.
Nozawa R, Boteva L, Soares D, Naughton C, Dun A, Buckle A, et al.
Cell
. 2017 Jun;
169(7):1214-1227.e18.
PMID: 28622508
Higher eukaryotic chromosomes are organized into topologically constrained functional domains; however, the molecular mechanisms required to sustain these complex interphase chromatin structures are unknown. A stable matrix underpinning nuclear organization...
16.
Nozawa R, Gilbert N
Cell
. 2014 Mar;
156(5):864-5.
PMID: 24581484
RNA has been proposed to be a component of an underlying nuclear matrix. Hall et al. show that noncoding, repetitive RNAs, some derived from LINE1 elements, stably associate with interphase...
17.
Nozawa R, Nagao K, Igami K, Shibata S, Shirai N, Nozaki N, et al.
Nat Struct Mol Biol
. 2013 Apr;
20(5):566-73.
PMID: 23542155
Human inactive X chromosome (Xi) forms a compact structure called the Barr body, which is enriched in repressive histone modifications such as trimethylation of histone H3 Lys9 (H3K9me3) and Lys27...
18.
19.
Nozawa R, Nagao K, Masuda H, Iwasaki O, Hirota T, Nozaki N, et al.
Nat Cell Biol
. 2010 Jun;
12(7):719-27.
PMID: 20562864
Heterochromatin protein 1 (HP1) has an essential role in heterochromatin formation and mitotic progression through its interaction with various proteins. We have identified a unique HP1alpha-binding protein, POGZ (pogo transposable...
20.
Osakabe A, Tachiwana H, Matsunaga T, Shiga T, Nozawa R, Obuse C, et al.
J Biol Chem
. 2010 Feb;
285(16):11913-21.
PMID: 20167597
NASP (nuclear autoantigenic sperm protein) is a member of the N1/N2 family, which is widely conserved among eukaryotes. Human NASP reportedly prefers to bind to histones H3.H4 and the linker...