Ryu-Suke Nozawa
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Explore the profile of Ryu-Suke Nozawa including associated specialties, affiliations and a list of published articles.
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758
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Recent Articles
1.
Matsui S, Nozawa R, Hirota T
Curr Opin Cell Biol
. 2025 Jan;
92():102462.
PMID: 39818167
Stable transmission of the genome during cell division is crucial for all life forms and is universally achieved by Aurora B-mediated error correction of the kinetochore-microtubule attachments. Aurora B is...
2.
Chiang M, Brackley C, Naughton C, Nozawa R, Battaglia C, Marenduzzo D, et al.
Cell Genom
. 2024 Nov;
4(12):100698.
PMID: 39591973
Classical observations suggest a connection between 3D gene structure and function, but testing this hypothesis has been challenging due to technical limitations. To explore this, we developed epigenetic highly predictive...
3.
Sako K, Furukawa A, Nozawa R, Kurita J, Nishimura Y, Hirota T
J Cell Biol
. 2024 May;
223(9).
PMID: 38781028
Maintenance of ploidy depends on the mitotic kinase Aurora B, the catalytic subunit of the chromosomal passenger complex (CPC) whose proficient activity is supported by HP1 enriched at inner centromeres....
4.
Mahana Y, Ariyoshi M, Nozawa R, Shibata S, Nagao K, Obuse C, et al.
Structure
. 2023 Dec;
32(3):304-315.e5.
PMID: 38159574
SETDB1 and SETDB2 mediate trimethylation of histone H3 lysine 9 (H3K9), an epigenetic hallmark of repressive chromatin. They contain a non-canonical methyl-CpG-binding domain (MBD) and bifurcated SET domain, implying interplay...
5.
Hara M, Ariyoshi M, Sano T, Nozawa R, Shinkai S, Onami S, et al.
Mol Cell
. 2023 Jun;
83(13):2188-2205.e13.
PMID: 37295434
Kinetochore is an essential protein complex required for accurate chromosome segregation. The constitutive centromere-associated network (CCAN), a subcomplex of the kinetochore, associates with centromeric chromatin and provides a platform for...
6.
Naughton C, Huidobro C, Catacchio C, Buckle A, Grimes G, Nozawa R, et al.
Nat Commun
. 2022 Sep;
13(1):5609.
PMID: 36153345
Human centromeres appear as constrictions on mitotic chromosomes and form a platform for kinetochore assembly in mitosis. Biophysical experiments led to a suggestion that repetitive DNA at centromeric regions form...
7.
Kitajima S, Tani T, Springer B, Campisi M, Osaki T, Haratani K, et al.
Cancer Cell
. 2022 Sep;
40(10):1128-1144.e8.
PMID: 36150391
KRAS-LKB1 (KL) mutant lung cancers silence STING owing to intrinsic mitochondrial dysfunction, resulting in T cell exclusion and resistance to programmed cell death (ligand) 1 (PD-[L]1) blockade. Here we discover...
8.
Matsui S, Nozawa R
Biomed Res
. 2021 Aug;
42(4):153-160.
PMID: 34380923
Biomolecular condensates are membrane-less compartments that are formed through an assembly of proteins and nucleic acids in the cell. Dysregulation of biological condensates has been implicated in diseases such as...
9.
Boteva L, Nozawa R, Naughton C, Samejima K, Earnshaw W, Gilbert N
Cell Rep
. 2020 Sep;
32(12):108177.
PMID: 32966795
Cells coordinate interphase-to-mitosis transition, but recurrent cytogenetic lesions appear at common fragile sites (CFSs), termed CFS expression, in a tissue-specific manner after replication stress, marking regions of instability in cancer....
10.
Kinjo K, Nagasaki K, Muroya K, Suzuki E, Ishiwata K, Nakabayashi K, et al.
Sci Rep
. 2020 Jul;
10(1):10985.
PMID: 32620854
Isolated hypogonadotropic hypogonadism (IHH), combined pituitary hormone deficiency (CPHD), and septo-optic dysplasia (SOD) constitute a disease spectrum whose etiology remains largely unknown. This study aimed to clarify whether mutations in...