Ryszard Kole
Overview
Explore the profile of Ryszard Kole including associated specialties, affiliations and a list of published articles.
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49
Citations
2710
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Recent Articles
1.
Dang Y, van Heusden C, Nickerson V, Chung F, Wang Y, Quinney N, et al.
Nucleic Acids Res
. 2021 Jun;
49(11):6100-6113.
PMID: 34107015
Pulmonary diseases offer many targets for oligonucleotide therapeutics. However, effective delivery of oligonucleotides to the lung is challenging. For example, splicing mutations in the cystic fibrosis transmembrane conductance regulator (CFTR)...
2.
Erdos M, Cabral W, Tavarez U, Cao K, Gvozdenovic-Jeremic J, Narisu N, et al.
Nat Med
. 2021 Mar;
27(3):536-545.
PMID: 33707773
Hutchinson-Gilford progeria syndrome (HGPS) is a rare accelerated aging disorder characterized by premature death from myocardial infarction or stroke. It is caused by de novo single-nucleotide mutations in the LMNA...
3.
dArqom A, Nualkaew T, Jearawiriyapaisarn N, Kole R, Svasti S
Hum Gene Ther
. 2020 Sep;
32(9-10):473-480.
PMID: 32977730
Restoration of correct splicing of β-globin pre-mRNA was previously accomplished in erythroid cells from β-thalassemia/HbE patients by an engineered U7 small nuclear RNA (snRNA) that carried a sequence targeted to...
4.
Nualkaew T, Jearawiriyapaisarn N, Hongeng S, Fucharoen S, Kole R, Svasti S
Sci Rep
. 2019 May;
9(1):7672.
PMID: 31113996
A cytosine to thymine mutation at nucleotide 654 of human β-globin intron 2 (β) is one of the most common mutations causing β-thalassaemia in Chinese and Southeast Asians. This mutation...
5.
Preedagasamzin S, Nualkaew T, Pongrujikorn T, Jinawath N, Kole R, Fucharoen S, et al.
Biochem Biophys Res Commun
. 2018 Mar;
499(1):86-92.
PMID: 29550480
Repair of a splicing defect of β-globin pre-mRNA harboring hemoglobin E (HbE) mutation was successfully accomplished in erythroid cells from patients with β-thalassemia/HbE disorder by a synthetic splice-switching oligonucleotide (SSO)....
6.
Echigoya Y, Nakamura A, Nagata T, Urasawa N, Lim K, Trieu N, et al.
Proc Natl Acad Sci U S A
. 2017 Apr;
114(16):4213-4218.
PMID: 28373570
Duchenne muscular dystrophy (DMD) is a lethal genetic disorder caused by an absence of the dystrophin protein in bodywide muscles, including the heart. Cardiomyopathy is a leading cause of death...
7.
Graziewicz M, Tarrant T, Buckley B, Roberts J, Fulton L, Hansen H, et al.
Mol Ther
. 2017 Feb;
16(7):1316-1322.
PMID: 28178484
Tumor necrosis factor-α (TNF-α) is a key mediator of inflammatory diseases, including rheumatoid arthritis (RA), and anti-TNF-α drugs such as etanercept are effective treatments. Splice-switching oligonucleotides (SSOs) are a new...
8.
Chiper M, Tounsi N, Kole R, Kichler A, Zuber G
J Control Release
. 2016 Dec;
246:60-70.
PMID: 27956144
Efficiency of polyethylenimine (PEI) for nucleic acid delivery is affected by the size of the carrier and length of the nucleic acids. For instance, PEIs with molecular weights between 10-30kDa...
9.
Kole R, Krieg A
Adv Drug Deliv Rev
. 2015 May;
87:104-7.
PMID: 25980936
Duchenne muscular dystrophy (DMD) is caused mostly by internal deletions in the gene for dystrophin, a protein essential for maintaining muscle cell membrane integrity. These deletions abrogate the reading frame...
10.
Zaharieva I, Calissano M, Scoto M, Preston M, Cirak S, Feng L, et al.
PLoS One
. 2013 Nov;
8(11):e80263.
PMID: 24282529
Duchenne muscular Dystrophy (DMD) is an inherited disease caused by mutations in the dystrophin gene that disrupt the open reading frame, while in frame mutations result in Becker muscular dystrophy...