Ryo Motosugi
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Explore the profile of Ryo Motosugi including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
94
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Recent Articles
1.
Wang Y, Wang Y, Iriki T, Hashimoto E, Inami M, Hashimoto S, et al.
Nat Commun
. 2025 Feb;
16(1):1600.
PMID: 39952963
The proteasome plays a pivotal role in protein degradation, and its impairment is associated with various pathological conditions, including neurodegenerative diseases. It is well understood that Nrf1 coordinates the induction...
2.
Galka D, Ali T, Bast A, Niederleithinger M, Gerhardt E, Motosugi R, et al.
Aging Cell
. 2024 Feb;
23(5):e14128.
PMID: 38415292
Parkinson's disease (PD) is characterized by aggregation of α-synuclein (α-syn) into protein inclusions in degenerating brains. Increasing amounts of aggregated α-syn species indicate significant perturbation of cellular proteostasis. Altered proteostasis...
3.
Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin A, et al.
Cell Rep
. 2019 Nov;
29(9):2901-2916.e6.
PMID: 31775054
The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Recent studies including single-cell transcriptomic analyses have...
4.
Arata Y, Watanabe A, Motosugi R, Murakami R, Goto T, Hori S, et al.
Genes Cells
. 2019 Oct;
24(12):801-813.
PMID: 31621149
The proteasome degradation machinery is essential for a variety of cellular processes including senescence and T-cell immunity. Decreased proteasome activity is associated with the aging process; however, the regulation of...
5.
Arata Y, Watanabe A, Motosugi R, Iemura S, Natsume T, Mukai K, et al.
Genes Cells
. 2019 Jun;
24(8):559-568.
PMID: 31210371
Maintaining protein homeostasis is central to cell survival. The ubiquitin-proteasome system and autophagy play pivotal roles in protein quality control through protein degradation. Activities of these degradative pathways are carefully...
6.
Motosugi R, Murata S
Front Mol Biosci
. 2019 May;
6:30.
PMID: 31119134
The 26S proteasome is a multisubunit complex that catalyzes the degradation of ubiquitinated proteins. The proteasome comprises 33 distinct subunits, all of which are essential for its function and structure....
7.
Uddin M, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, et al.
Nat Commun
. 2017 Feb;
8:14419.
PMID: 28176764
The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however,...