Yousuke Takahama
Overview
Explore the profile of Yousuke Takahama including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
140
Citations
5613
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
2.
Anderson G, Cosway E, James K, Ohigashi I, Takahama Y
J Exp Med
. 2024 Sep;
221(10).
PMID: 39264842
No abstract available.
3.
Yang M, Li J, Matsuda-Lennikov M, Crossman A, Takahama Y
J Vis Exp
. 2024 Aug;
(209).
PMID: 39141542
Thymic epithelial cells (TECs) play an essential role in promoting the development and repertoire selection of T cells. Cortical TECs (cTECs) in the thymic cortex induce early T cell development...
4.
Anderson G, Cosway E, James K, Ohigashi I, Takahama Y
J Exp Med
. 2024 Jul;
221(10).
PMID: 38980292
In the vertebrate immune system, thymus stromal microenvironments support the generation of αβT cells from immature thymocytes. Thymic epithelial cells are of particular importance, and the generation of cortical and...
5.
Ushio A, Matsuda-Lennikov M, Kalle-Youngoue F, Shimizu A, Abdelmaksoud A, Kelly M, et al.
Cell Rep
. 2024 Apr;
43(4):114072.
PMID: 38581680
Medullary thymic epithelial cells (mTECs) are essential for the establishment of self-tolerance in T cells. Promiscuous gene expression by a subpopulation of mTECs regulated by the nuclear protein Aire contributes...
6.
Ohigashi I, White A, Yang M, Fujimori S, Tanaka Y, Jacques A, et al.
Elife
. 2024 Mar;
12.
PMID: 38466627
Thymus medulla epithelium establishes immune self-tolerance and comprises diverse cellular subsets. Functionally relevant medullary thymic epithelial cells (mTECs) include a self-antigen-displaying subset that exhibits genome-wide promiscuous gene expression promoted by...
7.
Ohigashi I, White A, Yang M, Fujimori S, Tanaka Y, Jacques A, et al.
bioRxiv
. 2023 Oct;
PMID: 37873155
Thymus medulla epithelium establishes immune self-tolerance and comprises diverse cellular subsets. Functionally relevant medullary thymic epithelial cells (mTECs) include a self-antigen-displaying subset that exhibits genome-wide promiscuous gene expression promoted by...
8.
Fujie R, Kurowarabe K, Yamada Y, Fujiwara K, Nakatani H, Tsutsumi K, et al.
Heliyon
. 2023 Sep;
9(8):e19215.
PMID: 37664721
The chemokine CCL21 regulates immune and cancer cell migration through its receptor CCR7. The gene encodes the isoform CCL21-Ser, predominantly expressed in the thymic medulla and the secondary lymphoid tissues....
9.
Takahama Y
Curr Opin Immunol
. 2023 May;
83:102336.
PMID: 37210932
The thymoproteasome is a type of proteasome expressed specifically in thymic cortical epithelial cells. Thymoproteasome affects antigen processing of major histocompatibility complex (MHC)-I-associated peptides and optimizes positive selection of CD8...
10.
Lucas B, White A, Klein F, Veiga-Villauriz C, Handel A, Bacon A, et al.
Nat Commun
. 2023 Apr;
14(1):2066.
PMID: 37045811
The thymus medulla is a key site for immunoregulation and tolerance, and its functional specialisation is achieved through the complexity of medullary thymic epithelial cells (mTEC). While the importance of...