Jun Hamazaki
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Explore the profile of Jun Hamazaki including associated specialties, affiliations and a list of published articles.
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34
Citations
2295
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Recent Articles
1.
Wang Y, Wang Y, Iriki T, Hashimoto E, Inami M, Hashimoto S, et al.
Nat Commun
. 2025 Feb;
16(1):1600.
PMID: 39952963
The proteasome plays a pivotal role in protein degradation, and its impairment is associated with various pathological conditions, including neurodegenerative diseases. It is well understood that Nrf1 coordinates the induction...
2.
Mori Y, Akizuki Y, Honda R, Takao M, Tsuchimoto A, Hashimoto S, et al.
Nat Commun
. 2024 Jul;
15(1):5379.
PMID: 38956052
Targeted protein degradation is a groundbreaking modality in drug discovery; however, the regulatory mechanisms are still not fully understood. Here, we identify cellular signaling pathways that modulate the targeted degradation...
3.
Hamazaki J, Murata S
J Biochem
. 2024 Feb;
175(5):473-480.
PMID: 38348509
Aging is a major risk factor for many diseases. Recent studies have shown that age-related disruption of proteostasis leads to the accumulation of abnormal proteins and that dysfunction of the...
4.
Iriki T, Iio H, Yasuda S, Masuta S, Kato M, Kosako H, et al.
Cell Rep
. 2023 Aug;
42(8):112880.
PMID: 37541257
The proteasome plays a central role in intracellular protein degradation. Age-dependent decline in proteasome activity is associated with cellular senescence and organismal aging; however, the mechanism by which the proteasome...
5.
Li Q, Ishii K, Kamoshita K, Takahashi K, Abuduwaili H, Takayama H, et al.
Endocrinology
. 2023 Apr;
164(6).
PMID: 37103220
Muscle atrophy is the cause and consequence of obesity. Proteasome dysfunction mediates obesity-induced endoplasmic reticulum (ER) stress and insulin resistance in the liver and adipose tissues. However, obesity-associated regulation of...
6.
Kanazawa N, Hemmi H, Kinjo N, Ohnishi H, Hamazaki J, Mishima H, et al.
Nat Commun
. 2021 Nov;
12(1):6819.
PMID: 34819510
Impaired proteasome activity due to genetic variants of certain subunits might lead to proteasome-associated autoinflammatory syndromes (PRAAS). Here we report a de novo heterozygous missense variant of the PSMB9 proteasome...
7.
Hashimoto E, Okuno S, Hirayama S, Arata Y, Goto T, Kosako H, et al.
iScience
. 2020 Jul;
23(7):101299.
PMID: 32634741
The proteasome is a therapeutic target in cancer, but resistance to proteasome inhibitors often develops owing to the induction of compensatory pathways. Through a genome-wide siRNA screen combined with RNA...
8.
Hamazaki J, Murata S
Int J Mol Sci
. 2020 May;
21(10).
PMID: 32456207
Protein folding is a substantively error prone process, especially when it occurs in the endoplasmic reticulum (ER). The highly exquisite machinery in the ER controls secretory protein folding, recognizes aberrant...
9.
Waku T, Nakamura N, Koji M, Watanabe H, Katoh H, Tatsumi C, et al.
Mol Cell Biol
. 2020 Mar;
40(10).
PMID: 32123008
Proteasomes are essential protease complexes that maintain cellular homeostasis, and aberrant proteasomal activity supports cancer development. The regulatory mechanisms and biological function of the ubiquitin-26S proteasome have been studied extensively,...
10.
Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin A, et al.
Cell Rep
. 2019 Nov;
29(9):2901-2916.e6.
PMID: 31775054
The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Recent studies including single-cell transcriptomic analyses have...