Ryan J Cornelius
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Explore the profile of Ryan J Cornelius including associated specialties, affiliations and a list of published articles.
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25
Citations
276
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Recent Articles
1.
Cornelius R, Maeoka Y, Shinde U, McCormick J
Compr Physiol
. 2024 Dec;
14(5):5839-5874.
PMID: 39699086
The rare disease Familial Hyperkalemic Hypertension (FHHt) is caused by mutations in the genes encoding Cullin 3 (CUL3), Kelch-Like 3 (KLHL3), and two members of the With-No-Lysine [K] (WNK) kinase...
2.
Maeoka Y, Bradford T, Su X, Sharma A, Yang C, Ellison D, et al.
Am J Physiol Renal Physiol
. 2024 Aug;
327(4):F667-F682.
PMID: 39205661
The disease familial hyperkalemic hypertension (FHHt; also known as Gordon syndrome) is caused by aberrant accumulation of with-no-lysine kinase (WNK4) activating the NaCl cotransporter (NCC) in the distal convoluted tubule...
3.
Su X, Reyes J, Lackey A, Demirci H, Bachmann S, Maeoka Y, et al.
J Am Soc Nephrol
. 2024 Jan;
35(4):426-440.
PMID: 38238903
Significance Statement: High-resolution single-nucleus RNA-sequencing data indicate a clear separation between primary sites of calcium and magnesium handling within distal convoluted tubule (DCT). Both DCT1 and DCT2 express Slc12a3, but...
4.
Maeoka Y, Nguyen L, Sharma A, Cornelius R, Su X, Gutierrez M, et al.
Am J Physiol Renal Physiol
. 2023 Oct;
326(1):F39-F56.
PMID: 37881876
The with-no-lysine kinase 4 (WNK4)-sterile 20/SPS-1-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase 1 (OSR1) pathway mediates activating phosphorylation of the furosemide-sensitive Na-K-2Cl cotransporter (NKCC2) and the thiazide-sensitive NaCl cotransporter (NCC). The...
5.
Cornelius R, Maeoka Y, McCormick J
Curr Opin Nephrol Hypertens
. 2023 Apr;
32(4):335-343.
PMID: 37070483
Purpose Of Review: Mutations in the E3 ubiquitin ligase scaffold cullin 3 (CUL3) cause the disease familial hyperkalemic hypertension (FHHt) by hyperactivating the NaCl cotransporter (NCC). The effects of these...
6.
Maeoka Y, Cornelius R, McCormick J
Hypertension
. 2023 Mar;
80(5):912-923.
PMID: 36861484
The study of rare monogenic forms of hypertension has led to the elucidation of important physiological pathways controlling blood pressure. Mutations in several genes cause familial hyperkalemic hypertension (also known...
7.
Maeoka Y, Cornelius R, Ferdaus M, Sharma A, Nguyen L, McCormick J
Am J Physiol Renal Physiol
. 2022 Aug;
323(5):F564-F576.
PMID: 36007890
Mutations in the ubiquitin ligase scaffold protein cullin 3 (CUL3) cause the disease familial hyperkalemic hypertension (FHHt). We recently reported that in the kidney, aberrant mutant CUL3 (CUL3-Δ9) activity lowers...
8.
Cornelius R, Nelson J, Su X, Yang C, Ellison D
Am J Physiol Renal Physiol
. 2022 May;
323(1):F4-F19.
PMID: 35532068
Cullin-RING ligases are a family of E3 ubiquitin ligases that control cellular processes through regulated degradation. Cullin 3 targets with-no-lysine kinase 4 (WNK4), a kinase that activates the Na-Cl cotransporter...
9.
Maeoka Y, Ferdaus M, Cornelius R, Sharma A, Su X, Miller L, et al.
J Am Soc Nephrol
. 2022 Jan;
33(3):584-600.
PMID: 35064051
Background: Mutations in the ubiquitin ligase scaffold protein Cullin 3 () gene cause the disease familial hyperkalemic hypertension (FHHt). In the kidney, mutant () increases abundance of With-No-Lysine (K) Kinase...
10.
Cornelius R, Sharma A, Su X, Guo J, McMahon J, Ellison D, et al.
Am J Physiol Renal Physiol
. 2020 Jul;
319(3):F423-F435.
PMID: 32657158
Cre-lox technology has revolutionized research in renal physiology by allowing site-specific genetic recombination in individual nephron segments. The distal convoluted tubule (DCT), consisting of distinct early (DCT1) and late (DCT2)...