James A McCormick
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Explore the profile of James A McCormick including associated specialties, affiliations and a list of published articles.
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70
Citations
2025
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Recent Articles
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Cornelius R, Maeoka Y, Shinde U, McCormick J
Compr Physiol
. 2024 Dec;
14(5):5839-5874.
PMID: 39699086
The rare disease Familial Hyperkalemic Hypertension (FHHt) is caused by mutations in the genes encoding Cullin 3 (CUL3), Kelch-Like 3 (KLHL3), and two members of the With-No-Lysine [K] (WNK) kinase...
3.
Maeoka Y, Bradford T, Su X, Sharma A, Yang C, Ellison D, et al.
Am J Physiol Renal Physiol
. 2024 Aug;
327(4):F667-F682.
PMID: 39205661
The disease familial hyperkalemic hypertension (FHHt; also known as Gordon syndrome) is caused by aberrant accumulation of with-no-lysine kinase (WNK4) activating the NaCl cotransporter (NCC) in the distal convoluted tubule...
4.
Omage K, McCormick J
Kidney360
. 2024 Aug;
5(9):1386-1393.
PMID: 39120943
The sodium chloride cotransporter (NCC) fine-tunes Na + balance and indirectly affects the homeostasis of other ions including K + , Mg 2+ , and Ca 2+ . Owing to...
5.
Castro P, Santos-Rios T, Martins F, Crajoinas R, Caetano M, Lessa L, et al.
Am J Physiol Cell Physiol
. 2024 Apr;
326(6):C1573-C1589.
PMID: 38557357
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) reduce blood pressure (BP) in patients with hypertension, yet the precise molecular mechanisms remain elusive. SGLT2i inhibits proximal tubule (PT) NHE3-mediated sodium reabsorption in normotensive rodents,...
6.
Murali S, McCormick J, Fenton R
Am J Physiol Renal Physiol
. 2024 Mar;
326(5):F814-F826.
PMID: 38545647
Aquaporin 2 (AQP2) is a vasopressin (VP)-regulated water channel in the renal collecting duct. Phosphorylation and ubiquitylation of AQP2 play an essential role in controlling the cellular abundance of AQP2...
7.
Su X, Reyes J, Lackey A, Demirci H, Bachmann S, Maeoka Y, et al.
J Am Soc Nephrol
. 2024 Jan;
35(4):426-440.
PMID: 38238903
Significance Statement: High-resolution single-nucleus RNA-sequencing data indicate a clear separation between primary sites of calcium and magnesium handling within distal convoluted tubule (DCT). Both DCT1 and DCT2 express Slc12a3, but...
8.
Maeoka Y, Nguyen L, Sharma A, Cornelius R, Su X, Gutierrez M, et al.
Am J Physiol Renal Physiol
. 2023 Oct;
326(1):F39-F56.
PMID: 37881876
The with-no-lysine kinase 4 (WNK4)-sterile 20/SPS-1-related proline/alanine-rich kinase (SPAK)/oxidative stress-responsive kinase 1 (OSR1) pathway mediates activating phosphorylation of the furosemide-sensitive Na-K-2Cl cotransporter (NKCC2) and the thiazide-sensitive NaCl cotransporter (NCC). The...
9.
Cornelius R, Maeoka Y, McCormick J
Curr Opin Nephrol Hypertens
. 2023 Apr;
32(4):335-343.
PMID: 37070483
Purpose Of Review: Mutations in the E3 ubiquitin ligase scaffold cullin 3 (CUL3) cause the disease familial hyperkalemic hypertension (FHHt) by hyperactivating the NaCl cotransporter (NCC). The effects of these...
10.
Ellison D, McCormick J
J Am Soc Nephrol
. 2023 Apr;
34(6):937-938.
PMID: 37052952
No abstract available.