Ryan F L OShaughnessy
Overview
Explore the profile of Ryan F L OShaughnessy including associated specialties, affiliations and a list of published articles.
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26
Citations
384
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Recent Articles
1.
Hughes A, Barbosa E, Cernova J, Thomas B, OShaughnessy R, OToole E
Clin Exp Dermatol
. 2024 May;
49(12):1547-1553.
PMID: 38747172
Background: Acne vulgaris (AV) is the eighth most common nonfatal disease globally. Previous work identified an association between AV and increased filaggrin (FLG) protein expression in the follicular epidermis, but...
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Tagoe H, Hassan S, Bliss E, Youssef G, Heywood W, Mills K, et al.
Br J Dermatol
. 2023 Mar;
189(1):91-102.
PMID: 36972303
Background: Ichthyosis defines a group of chronic conditions that manifest phenotypically as a thick layer of scales, often affecting the entire skin. While the gene mutations that lead to ichthyosis...
4.
Rogerson C, Wotherspoon D, Tommasi C, Button R, OShaughnessy R
Cell Death Differ
. 2021 Jan;
28(6):1849-1864.
PMID: 33462407
Keratinocyte cornification and epidermal barrier formation are tightly controlled processes, which require complete degradation of intracellular organelles, including removal of keratinocyte nuclei. Keratinocyte nuclear destruction requires Akt1-dependent phosphorylation and degradation...
5.
Wotherspoon D, Rogerson C, OShaughnessy R
J Dev Biol
. 2020 Dec;
8(4).
PMID: 33291764
The outer layer of the skin, the epidermis, is the principal barrier to the external environment: post-mitotic cells terminally differentiate to form a tough outer cornified layer of enucleate and...
6.
Tommasi C, Rogerson C, Depledge D, Jones M, Naeem A, Venturini C, et al.
J Invest Dermatol
. 2019 Oct;
140(4):774-784.e11.
PMID: 31626786
Varicella zoster virus (VZV) is a skin-tropic virus that infects epidermal keratinocytes and causes chickenpox. Although common, VZV infection can be life-threatening, particularly in the immunocompromized. Therefore, understanding VZV-keratinocyte interactions...
7.
Papaioannou E, Yanez D, Ross S, Lau C, Solanki A, Chawda M, et al.
J Clin Invest
. 2019 Jul;
129(8):3153-3170.
PMID: 31264977
Hedgehog (Hh) proteins regulate development and tissue homeostasis, but their role in atopic dermatitis (AD) remains unknown. We found that on induction of mouse AD, Sonic Hedgehog (Shh) expression in...
8.
Rogerson C, OShaughnessy R
Exp Dermatol
. 2018 May;
27(8):892-900.
PMID: 29845670
Formation of a stratified epidermis is required for the performance of the essential functions of the skin; to act as an outside-in barrier against the access of microorganisms and other...
9.
Rogerson C, Bergamaschi D, OShaughnessy R
Nucleus
. 2017 Dec;
9(1):56-64.
PMID: 29205081
Eukaryotic nuclei are essential organelles, storing the majority of the cellular DNA, comprising the site of most DNA and RNA synthesis, controlling gene expression and therefore regulating cellular function. The...
10.
Janus J, OShaughnessy R, Harwood C, Maffucci T
Cancers (Basel)
. 2017 Jul;
9(7).
PMID: 28696382
Cutaneous squamous cell carcinoma (cSCC) derives from keratinocytes in the epidermis and accounts for 15-20% of all cutaneous malignancies. Although it is usually curable by surgery, 5% of these tumours...