Ryan C Schoenfeld
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Explore the profile of Ryan C Schoenfeld including associated specialties, affiliations and a list of published articles.
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14
Citations
94
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Recent Articles
1.
Straccia M, Garcia-Diaz Barriga G, Sanders P, Bombau G, Carrere J, Mairal P, et al.
Mol Ther Methods Clin Dev
. 2015 Sep;
2:15030.
PMID: 26417608
A systematic characterization of the spatio-temporal gene expression during human neurodevelopment is essential to understand brain function in both physiological and pathological conditions. In recent years, stem cell technology has...
2.
Fodale V, Kegulian N, Verani M, Cariulo C, Azzollini L, Petricca L, et al.
PLoS One
. 2014 Dec;
9(12):e112262.
PMID: 25464275
Background: In Huntington's disease, expansion of a CAG triplet repeat occurs in exon 1 of the huntingtin gene (HTT), resulting in a protein bearing>35 polyglutamine residues whose N-terminal fragments display...
3.
Sidduri A, Budd D, Fuentes M, Lambros T, Ren Y, Roongta V, et al.
Bioorg Med Chem Lett
. 2014 Aug;
24(18):4450-4454.
PMID: 25155385
High throughput screening (HTS) of our chemical library identified 3-alkylamino-2-aryl-5H-imidazo[1,2,b]pyrazol-7-carbonitrile 1 as a potent antagonist of the LPA1 receptor (LPA1R). Further evaluation of this class of compounds indicated that LPA1R...
4.
Talamas F, Abbot S, Anand S, Brameld K, Carter D, Chen J, et al.
J Med Chem
. 2013 Nov;
57(5):1914-31.
PMID: 24195700
In the past few years, there have been many advances in the efforts to cure patients with hepatitis C virus (HCV). The ultimate goal of these efforts is to develop...
5.
Schoenfeld R, Bourdet D, Brameld K, Chin E, De Vicente J, Fung A, et al.
J Med Chem
. 2013 Sep;
56(20):8163-82.
PMID: 24069953
Hepatitis C virus (HCV) is a major global public health problem. While the current standard of care, a direct-acting antiviral (DAA) protease inhibitor taken in combination with pegylated interferon and...
6.
Talamas F, Ao-Ieong G, Brameld K, Chin E, De Vicente J, Dunn J, et al.
J Med Chem
. 2013 Mar;
56(7):3115-9.
PMID: 23509929
The use of fragments with low binding affinity for their targets as starting points has received much attention recently. Screening of fragment libraries has been the most common method to...
7.
Padilla F, Bhagirath N, Chen S, Chiao E, Goldstein D, Hermann J, et al.
J Med Chem
. 2013 Jan;
56(4):1677-92.
PMID: 23350847
We describe the discovery of several pyrrolopyrazines as potent and selective Syk inhibitors and the efforts that eventually led to the desired improvements in physicochemical properties and human whole blood...
8.
Qian Y, Hamilton M, Sidduri A, Gabriel S, Ren Y, Peng R, et al.
J Med Chem
. 2012 Aug;
55(17):7920-39.
PMID: 22894757
Lysophosphatidic acid is a class of bioactive phospholipid that mediates most of its biological effects through LPA receptors, of which six isoforms have been identified. The recent results from LPA1...
9.
Lucas M, Weikert R, Carter D, Cai H, Greenhouse R, Iyer P, et al.
Bioorg Med Chem Lett
. 2010 Aug;
20(18):5559-66.
PMID: 20691589
Two new series of monoamine triple reuptake inhibitors (TRIs) have been discovered through scaffold homologation of our recently reported series of 3,3-disubstituted pyrrolidine TRIs. The regioisomeric 2- and 3-ketopyrrolidines demonstrated...
10.
2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression
Carter D, Cai H, Lee E, Iyer P, Lucas M, Roetz R, et al.
Bioorg Med Chem Lett
. 2010 Jun;
20(13):3941-5.
PMID: 20570146
Recently a class of compounds known as triple reuptake inhibitors has emerged as a new strategy for the treatment of depression. These compounds work by simultaneously inhibiting the synaptic reuptake...