Ruth Sperling
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Explore the profile of Ruth Sperling including associated specialties, affiliations and a list of published articles.
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39
Citations
768
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Recent Articles
1.
Arafat M, Sperling R
Noncoding RNA
. 2023 Aug;
9(4).
PMID: 37624034
Non-coding RNAs (ncRNAs) play diverse roles in regulating cellular processes and have been implicated in pathological conditions, including cancer, where interactions between ncRNAs play a role. Relevant here are (i)...
2.
Arafat M, Sperling R
Cancers (Basel)
. 2022 Apr;
14(7).
PMID: 35406522
Latent 5' splice sites, highly abundant in human introns, are not normally used. This led to the proposal of a quality control mechanism, Suppression of Splicing (SOS), which protects cells...
3.
Shefer K, Boulos A, Gotea V, Arafat M, Ben Chaim Y, Muharram A, et al.
RNA Biol
. 2022 Feb;
19(1):333-352.
PMID: 35220879
Latent 5' splice sites, not normally used, are highly abundant in human introns, but are activated under stress and in cancer, generating thousands of nonsense mRNAs. A previously proposed mechanism...
4.
Mahlab-Aviv S, Zohar K, Cohen Y, Peretz A, Eliyahu T, Linial M, et al.
Int J Mol Sci
. 2020 Nov;
21(21).
PMID: 33143250
MicroRNAs (miRNAs) act as negative regulators of gene expression in the cytoplasm. Previous studies have identified the presence of miRNAs in the nucleus. Here we study human breast cancer-derived cell-lines...
5.
Sebbag-Sznajder N, Brody Y, Hochberg-Laufer H, Shav-Tal Y, Sperling J, Sperling R
Front Genet
. 2020 Jun;
11:409.
PMID: 32499811
Splicing and alternative splicing of pre-mRNA are key sources in the formation of diversity in the human proteome. These processes have a central role in the regulation of the gene...
6.
Sperling R
Biochim Biophys Acta Gene Regul Mech
. 2019 Jul;
1862(11-12):194406.
PMID: 31323432
Splicing and alternative splicing (AS), which occur in the endogenous spliceosome, play major roles in regulating gene expression, and defects in them are involved in numerous human diseases including cancer....
7.
Mahlab-Aviv S, Boulos A, Peretz A, Eliyahu T, Carmel L, Sperling R, et al.
Nucleic Acids Res
. 2018 Sep;
46(20):11014-11029.
PMID: 30203035
MicroRNAs (miRNAs) are short non-coding RNAs that negatively regulate the expression and translation of genes in healthy and diseased tissues. Herein, we characterize short RNAs from human HeLa cells found...
8.
Sperling J, Sperling R
Methods
. 2017 Apr;
125:70-83.
PMID: 28412289
Pre-mRNA splicing is executed in mammalian cell nuclei within a huge (21MDa) and highly dynamic molecular machine - the supraspliceosome - that individually package pre-mRNA transcripts of different sizes and...
9.
Sperling R
Wiley Interdiscip Rev RNA
. 2016 Jul;
8(1).
PMID: 27465259
The complex life of pre-mRNA from transcription to the production of mRNA that can be exported from the nucleus to the cytoplasm to encode for proteins entails intricate coordination and...
10.
Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing
Falaleeva M, Pages A, Matuszek Z, Hidmi S, Agranat-Tamir L, Korotkov K, et al.
Proc Natl Acad Sci U S A
. 2016 Mar;
113(12):E1625-34.
PMID: 26957605
C/D box small nucleolar RNAs (SNORDs) are small noncoding RNAs, and their best-understood function is to target the methyltransferase fibrillarin to rRNA (for example, SNORD27 performs 2'-O-methylation of A27 in...