Joseph Sperling
Overview
Explore the profile of Joseph Sperling including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
612
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Recent Articles
1.
Warbinek J, Rickert E, Raeder S, Albrecht-Schonzart T, Andelic B, Auler J, et al.
Nature
. 2024 Oct;
634(8036):1075-1079.
PMID: 39478208
The quantum-mechanical nuclear-shell structure determines the stability and limits of the existence of the heaviest nuclides with large proton numbers Z ≳ 100 (refs. ). Shell effects also affect the...
2.
Shefer K, Boulos A, Gotea V, Arafat M, Ben Chaim Y, Muharram A, et al.
RNA Biol
. 2022 Feb;
19(1):333-352.
PMID: 35220879
Latent 5' splice sites, not normally used, are highly abundant in human introns, but are activated under stress and in cancer, generating thousands of nonsense mRNAs. A previously proposed mechanism...
3.
Zhuravel R, Huang H, Polycarpou G, Polydorides S, Motamarri P, Katrivas L, et al.
Nat Nanotechnol
. 2020 Aug;
15(10):836-840.
PMID: 32807877
Understanding charge transport in DNA molecules is a long-standing problem of fundamental importance across disciplines. It is also of great technological interest due to DNA's ability to form versatile and...
4.
Sebbag-Sznajder N, Brody Y, Hochberg-Laufer H, Shav-Tal Y, Sperling J, Sperling R
Front Genet
. 2020 Jun;
11:409.
PMID: 32499811
Splicing and alternative splicing of pre-mRNA are key sources in the formation of diversity in the human proteome. These processes have a central role in the regulation of the gene...
5.
Sperling J, Sperling R
Methods
. 2017 Apr;
125:70-83.
PMID: 28412289
Pre-mRNA splicing is executed in mammalian cell nuclei within a huge (21MDa) and highly dynamic molecular machine - the supraspliceosome - that individually package pre-mRNA transcripts of different sizes and...
6.
Nevo Y, Sperling J, Sperling R
Nucleus
. 2015 Jan;
6(3):225-35.
PMID: 25634319
Pre-mRNA splicing is essential for the regulation of gene expression in eukaryotes and is fundamental in development and cancer, and involves the selection of a consensus sequence that defines the...
7.
Shefer K, Sperling J, Sperling R
Comput Struct Biotechnol J
. 2014 Nov;
11(19):113-22.
PMID: 25408845
Pre-mRNA splicing of Pol II transcripts is executed in the mammalian cell nucleus within a huge (21 MDa) and highly dynamic RNP machine - the supraspliceosome. It is composed of...
8.
Kotzer-Nevo H, de Lima Alves F, Rappsilber J, Sperling J, Sperling R
Int J Mol Sci
. 2014 Jul;
15(7):11637-64.
PMID: 24983480
When isolated from mammalian cell nuclei, all nuclear pre-mRNAs are packaged in multi-subunit large ribonucleoprotein complexes-supraspliceosomes-composed of four native spliceosomes interconnected by the pre-mRNA. Supraspliceosomes contain all five spliceosomal U...
9.
Agranat-Tamir L, Shomron N, Sperling J, Sperling R
Nucleic Acids Res
. 2014 Jan;
42(7):4640-51.
PMID: 24464992
MicroRNAs (miRNAs) are central regulators of gene expression, and a large fraction of them are encoded in introns of RNA polymerase II transcripts. Thus, the biogenesis of intronic miRNAs by...
10.
Zhang Z, Falaleeva M, Agranat-Tamir L, Pages A, Eyras E, Sperling J, et al.
Exp Brain Res
. 2013 Mar;
230(4):387-94.
PMID: 23494383
The serotonin receptor 2C (HTR2C) gene encodes a G protein-coupled receptor that is exclusively expressed in neurons. Here, we report that the 5' untranslated region of the receptor pre-mRNA as...