Rustin R Lovewell
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Explore the profile of Rustin R Lovewell including associated specialties, affiliations and a list of published articles.
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10
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545
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Recent Articles
1.
Lovewell R, Hong J, Kundu S, Fielder C, Hu Q, Kim K, et al.
J Clin Invest
. 2023 Nov;
133(22).
PMID: 37966113
Effective eradication of leukemic stem cells (LSCs) remains the greatest challenge in treating acute myeloid leukemia (AML). The immune receptor LAIR-1 has been shown to regulate LSC survival; however, the...
2.
Lovewell R, Baer C, Mishra B, Smith C, Sassetti C
Mucosal Immunol
. 2020 Jun;
14(1):229-241.
PMID: 32483198
Granulocyte recruitment to the pulmonary compartment is a hallmark of progressive tuberculosis (TB). This process is well-documented to promote immunopathology, but can also enhance the replication of the pathogen. Both...
3.
Mishra B, Lovewell R, Olive A, Zhang G, Wang W, Eugenin E, et al.
Nat Microbiol
. 2017 May;
2:17072.
PMID: 28504669
Nitric oxide contributes to protection from tuberculosis. It is generally assumed that this protection is due to direct inhibition of Mycobacterium tuberculosis growth, which prevents subsequent pathological inflammation. In contrast,...
4.
Lovewell R, Sassetti C, VanderVen B
Curr Opin Microbiol
. 2015 Nov;
29:30-6.
PMID: 26544033
The interplay between Mycobacterium tuberculosis lipid metabolism, the immune response and lipid homeostasis in the host creates a complex and dynamic pathogen-host interaction. Advances in imaging and metabolic analysis techniques...
5.
Lovewell R, Hayes S, OToole G, Berwin B
Am J Physiol Lung Cell Mol Physiol
. 2014 Feb;
306(7):L698-707.
PMID: 24487390
Phagocytosis of the bacterial pathogen Pseudomonas aeruginosa is the primary means by which the host controls bacterially induced pneumonia during lung infection. Previous studies have identified flagellar swimming motility as...
6.
Lovewell R, Patankar Y, Berwin B
Am J Physiol Lung Cell Mol Physiol
. 2014 Jan;
306(7):L591-603.
PMID: 24464809
Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for a high incidence of acute and chronic pulmonary infection. These infections are particularly prevalent in patients with chronic obstructive pulmonary disease...
7.
Patankar Y, Lovewell R, Poynter M, Jyot J, Kazmierczak B, Berwin B
Infect Immun
. 2013 Mar;
81(6):2043-52.
PMID: 23529619
We previously demonstrated that bacterial flagellar motility is a fundamental mechanism by which host phagocytes bind and ingest bacteria. Correspondingly, loss of bacterial motility, consistently observed in clinical isolates from...
8.
Lovewell R, Collins R, Acker J, OToole G, Wargo M, Berwin B
PLoS Pathog
. 2011 Sep;
7(9):e1002253.
PMID: 21949654
Phagocytosis of bacteria by innate immune cells is a primary method of bacterial clearance during infection. However, the mechanisms by which the host cell recognizes bacteria and consequentially initiates phagocytosis...
9.
Amiel E, Lovewell R, OToole G, Hogan D, Berwin B
Infect Immun
. 2010 May;
78(7):2937-45.
PMID: 20457788
Pseudomonas aeruginosa is a pathogenic Gram-negative bacterium that causes severe opportunistic infections in immunocompromised individuals; in particular, severity of infection with P. aeruginosa positively correlates with poor prognosis in cystic...
10.
Anderson G, Yahr T, Lovewell R, OToole G
Infect Immun
. 2009 Dec;
78(3):1239-49.
PMID: 20028803
Pseudomonas aeruginosa is an opportunistic pathogen that causes life-long pneumonia in individuals with cystic fibrosis (CF). These long-term infections are maintained by bacterial biofilm formation in the CF lung. We...