Russell A DeBose-Boyd
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Explore the profile of Russell A DeBose-Boyd including associated specialties, affiliations and a list of published articles.
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2949
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Recent Articles
1.
Faulkner R, Yang Y, Tsien J, Qin T, DeBose-Boyd R
Proc Natl Acad Sci U S A
. 2024 Feb;
121(7):e2318822121.
PMID: 38319967
The maintenance of cholesterol homeostasis is crucial for normal function at both the cellular and organismal levels. Two integral membrane proteins, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and Scap, are key...
2.
Jo Y, DeBose-Boyd R
Cold Spring Harb Perspect Biol
. 2022 Aug;
14(12).
PMID: 35940903
3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is an endoplasmic reticulum (ER)-localized integral membrane protein that catalyzes the rate-limiting step in the synthesis of cholesterol and many nonsterol isoprenoids including geranylgeranyl pyrophosphate...
3.
Chen H, Qi X, Faulkner R, Schumacher M, Donnelly L, DeBose-Boyd R, et al.
Nat Commun
. 2022 Jul;
13(1):4273.
PMID: 35879350
3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme in cholesterol synthesis and target of cholesterol-lowering statin drugs. Accumulation of sterols in endoplasmic reticulum (ER) membranes accelerates degradation of HMGCR,...
4.
Elsabrouty R, Jo Y, Hwang S, Jun D, DeBose-Boyd R
Elife
. 2021 Nov;
10.
PMID: 34842525
UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K subtype menaquinone-4. The prenyltransferase has emerged as a key regulator of sterol-accelerated, endoplasmic reticulum (ER)-associated degradation...
5.
Ellis J, Fu X, Karl J, Hernandez C, Mason J, DeBose-Boyd R, et al.
J Nutr
. 2021 Sep;
152(4):981-993.
PMID: 34550377
Background: Vitamin K is a term that comprises a family of structurally related quinones, phylloquinone (PK) and the menaquinones (MKn), that share a common naphthoquinone ring but vary in sidechain...
6.
Long T, Liu Y, Qin Y, DeBose-Boyd R, Li X
Sci Adv
. 2021 Aug;
7(34).
PMID: 34407950
Polytopic Niemann-Pick C1-like 1 (NPC1L1) plays a major role in intestinal absorption of biliary cholesterol, vitamin E (VE), and vitamin K (VK). The drug ezetimibe inhibits NPC1L1-mediated absorption of cholesterol,...
7.
Schumacher M, DeBose-Boyd R
Annu Rev Biochem
. 2021 Jun;
90:659-679.
PMID: 34153214
The polytopic, endoplasmic reticulum (ER) membrane protein 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase produces mevalonate, the key intermediate in the synthesis of cholesterol and many nonsterol isoprenoids including geranylgeranyl pyrophosphate...
8.
Jun D, Schumacher M, Hwang S, Kinch L, Grishin N, DeBose-Boyd R
J Lipid Res
. 2020 Mar;
61(5):746-757.
PMID: 32188638
The autosomal dominant disorder Schnyder corneal dystrophy (SCD) is caused by mutations in UbiA prenyltransferase domain-containing protein-1 (UBIAD1), which uses geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K subtype menaquinone-4...
9.
Jo Y, Kim S, Garland K, Fuentes I, DiCarlo L, Ellis J, et al.
Elife
. 2020 Mar;
9.
PMID: 32118581
UbiA prenyltransferase domain-containing protein-1 (UBIAD1) synthesizes the vitamin K subtype menaquinone-4 (MK-4). Previous studies in cultured cells (Schumacher et al., 2015) revealed that UBIAD1 also inhibits endoplasmic reticulum (ER)-associated degradation...
10.
Jo Y, Hamilton J, Hwang S, Garland K, Smith G, Su S, et al.
Elife
. 2019 Feb;
8.
PMID: 30785396
Autosomal-dominant Schnyder corneal dystrophy (SCD) is characterized by corneal opacification owing to overaccumulation of cholesterol. SCD is caused by mutations in UBIAD1, which utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin...