Ruhar Singh
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Explore the profile of Ruhar Singh including associated specialties, affiliations and a list of published articles.
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11
Citations
41
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Recent Articles
1.
Bali S, Singh R, Wydorski P, Wosztyl A, Perez V, Chen D, et al.
Res Sq
. 2024 Feb;
PMID: 38313287
The microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. Mutations associated with frontotemporal dementia increase tau aggregation propensity and disrupt its endogenous microtubule-binding activity. The structural...
2.
Bali S, Singh R, Wydorski P, Van Nuland N, Wosztyl A, Perez V, et al.
bioRxiv
. 2024 Jan;
PMID: 38168322
Abstract Figure:
3.
Hitt B, Gupta A, Singh R, Yang T, Beaver J, Shang P, et al.
J Biol Chem
. 2023 Sep;
299(11):105252.
PMID: 37714465
Neurodegenerative tauopathies are caused by the transition of tau protein from a monomer to a toxic aggregate. They include Alzheimer disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and...
4.
Chen D, Bali S, Singh R, Wosztyl A, Mullapudi V, Vaquer-Alicea J, et al.
Nat Commun
. 2023 Mar;
14(1):1625.
PMID: 36959205
Amyloid deposition of the microtubule-associated protein tau is associated with neurodegenerative diseases. In frontotemporal dementia with abnormal tau (FTD-tau), missense mutations in tau enhance its aggregation propensity. Here we describe...
5.
Singh R, Kumar A, Rane J, Khan R, Tripathi G, Ajay A, et al.
Sci Rep
. 2022 Oct;
12(1):17038.
PMID: 36220880
The vaccination drive against COVID-19 worldwide was quite successful. However, the second wave of infections was even more disastrous. There was a rapid increase in reinfections and human deaths due...
6.
Li R, Singh R, Kashav T, Yang C, Sharma R, Lynn A, et al.
Front Mol Neurosci
. 2022 May;
15:822863.
PMID: 35548668
TDP-43 proteinopathies is a disease hallmark that characterizes amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The N-terminal domain of TDP-43 (NTD) is important to both TDP-43 physiology and...
7.
Kumari M, Singh R, Subbarao N
J Biomol Struct Dyn
. 2021 Oct;
40(24):13497-13526.
PMID: 34662260
Multi-targeting enzyme approaches are considered to be the most significant in suppressing pathogen growth and disease control for MDR and XDR-resistant . The multiple Mur enzymes involved in peptidoglycan biosynthesis...
8.
Singh A, Verma A, Singh R, Sahoo A, Samanta S
Nanotechnology
. 2020 Oct;
32(8):085104.
PMID: 33080579
Nearly 80% of human chronic infections are caused due to bacterial biofilm formation. The increased resistance against the conventional antimicrobial agents makes it difficult to treat the biofilm-related infections. The...
9.
Singh R, Meena N, Das T, Sharma R, Prakash A, Lynn A
J Biomol Struct Dyn
. 2019 Nov;
38(17):5027-5036.
PMID: 31744390
The funnel shaped energy landscape model of the protein folding suggests that progression of folding proceeds through multiple pathways, having the multiple intermediates which leads to multidimensional free-energy surface. Herein,...
10.
Prakash A, Kumar V, Pandey P, Bharti D, Vishwakarma P, Singh R, et al.
J Biomol Struct Dyn
. 2017 Aug;
36(10):2605-2617.
PMID: 28782426
Misfolding and aggregation of Cu, Zn Superoxide Dismutase (SOD1) is often found in amyotrophic lateral sclerosis (ALS) patients. The central apo SOD1 barrel was involved in protein maturation and pathological...