Ruby Lieshout
Overview
Explore the profile of Ruby Lieshout including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
933
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0
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Recent Articles
1.
Koch M, Nickel S, Lieshout R, Lissek S, Leskova M, van der Laan L, et al.
Cells
. 2022 Nov;
11(22).
PMID: 36429040
Monitoring tumor growth dynamics is crucial for understanding cancer. To establish an in vitro method for the continuous assessment of patient-specific tumor growth, tumor organoids were generated from patients with...
2.
van Tienderen G, Rosmark O, Lieshout R, Willemse J, de Weijer F, Elowsson Rendin L, et al.
Acta Biomater
. 2022 Nov;
158:115-131.
PMID: 36427688
Patient-derived tumor organoids have been established as promising tools for in vitro modelling of multiple tumors, including cholangiocarcinoma (CCA). However, organoids are commonly cultured in basement membrane extract (BME) which...
3.
Lieshout R, Kamp E, Verstegen M, Doukas M, Dinjens W, Koten K, et al.
Int J Cancer
. 2022 Nov;
152(12):2607-2614.
PMID: 36346104
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of the biliary tree and a risk factor for development of cholangiocarcinoma (CCA). The pathogenesis of PSC-related CCA is largely unclear,...
4.
Lieshout R, Faria A, Peppelenbosch M, van der Laan L, Verstegen M, Fuhler G
Mol Med
. 2022 Jun;
28(1):74.
PMID: 35764936
Background: Cholangiocarcinoma is a rare but lethal cancer of the biliary tract. Its first-line treatment is currently restricted to chemotherapy, which provides limited clinical benefit. Kinase inhibitors targeting oncogenic intracellular...
5.
Zhou G, Lieshout R, van Tienderen G, de Ruiter V, van Royen M, Boor P, et al.
Br J Cancer
. 2022 May;
127(4):649-660.
PMID: 35597867
Background: Immunotherapy with immune checkpoint inhibitors (ICIs) is being explored to improve cholangiocarcinoma (CCA) therapy. However, it remains difficult to predict which ICI will be effective for individual patients. Therefore,...
6.
Roos F, Wu H, Willemse J, Lieshout R, Albarinos L, Kan Y, et al.
Clin Transl Med
. 2021 Dec;
11(12):e566.
PMID: 34954911
The well-established 3D organoid culture method enabled efficient expansion of cholangiocyte-like cells from intrahepatic (IHBD) and extrahepatic bile duct (EHBD) tissue biopsies. The extensive expansion capacity of these organoids enables...
7.
Nguyen L, Jager M, Lieshout R, de Ruiter P, Locati M, Besselink N, et al.
Commun Biol
. 2021 Nov;
4(1):1301.
PMID: 34795391
Inflammatory liver disease increases the risk of developing primary liver cancer. The mechanism through which liver disease induces tumorigenesis remains unclear, but is thought to occur via increased mutagenesis. Here,...
8.
Liu J, Li P, Wang L, Li M, Ge Z, Noordam L, et al.
Cell Mol Gastroenterol Hepatol
. 2020 Sep;
11(2):407-431.
PMID: 32932015
Background & Aims: Cancer-associated fibroblasts (CAFs) play a key role in the cancer process, but the research progress is hampered by the paucity of preclinical models that are essential for...
9.
Li M, Wang L, Wang Y, Zhang S, Zhou G, Lieshout R, et al.
Cells
. 2020 Jan;
9(1).
PMID: 31947947
Metabolic reprogramming universally occurs in cancer. Mitochondria act as the hubs of bioenergetics and metabolism. The morphodynamics of mitochondria, comprised of fusion and fission processes, are closely associated with mitochondrial...
10.
Schneeberger K, Sanchez-Romero N, Ye S, van Steenbeek F, Oosterhoff L, Palacin I, et al.
Hepatology
. 2019 Nov;
72(1):257-270.
PMID: 31715015
Background And Aims: The gap between patients on transplant waiting lists and available donor organs is steadily increasing. Human organoids derived from leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)-positive adult...