Jorke Willemse
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Explore the profile of Jorke Willemse including associated specialties, affiliations and a list of published articles.
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14
Citations
222
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Recent Articles
1.
Schurink I, Luijmes S, Willemse J, de Goeij F, Groen P, Kucukerbil E, et al.
Transplantation
. 2025 Mar;
PMID: 40045462
Background: Normothermic machine perfusion (NMP) enables pretransplantation assessment of donor liver viability to increase donor liver utilization. However, unambiguous objective criteria to determine integrated liver function during NMP to decide...
2.
Endothelial Cell Replacement of Human Veins, Modeling Vascular Repair and Endothelial Cell Chimerism
Tejeda-Mora H, den Hartog Y, Schurink I, Verstegen M, De Jonge J, van den Hoogen M, et al.
Stem Cells Dev
. 2023 Nov;
33(1-2):27-42.
PMID: 37950716
Allogeneic transplant organs are potentially highly immunogenic. The endothelial cells (ECs) located within the vascular system serve as the primary interface between the recipient's immune system and the donor organ,...
3.
van Tienderen G, Conboy J, Muntz I, Willemse J, Tieleman J, Monfils K, et al.
Biomater Adv
. 2023 Feb;
146:213289.
PMID: 36724550
Tumor initiation and progression are critically dependent on interaction of cancer cells with their cellular and extracellular microenvironment. Alterations in the composition, integrity, and mechanical properties of the extracellular matrix...
4.
van Tienderen G, Willemse J, van Loo B, van Hengel E, De Jonge J, van der Laan L, et al.
Cells
. 2022 Nov;
11(22).
PMID: 36429084
Advances in biomaterials, particularly in combination with encapsulation strategies, have provided excellent opportunities to increase reproducibility and standardization for cell culture applications. Herein, hybrid microcapsules are produced in a flow-focusing...
5.
van Tienderen G, Rosmark O, Lieshout R, Willemse J, de Weijer F, Elowsson Rendin L, et al.
Acta Biomater
. 2022 Nov;
158:115-131.
PMID: 36427688
Patient-derived tumor organoids have been established as promising tools for in vitro modelling of multiple tumors, including cholangiocarcinoma (CCA). However, organoids are commonly cultured in basement membrane extract (BME) which...
6.
Roos F, van Tienderen G, Wu H, Bordeu I, Vinke D, Albarinos L, et al.
Cell Stem Cell
. 2022 May;
29(5):776-794.e13.
PMID: 35523140
Human cholangiocyte organoids show great promise for regenerative therapies and in vitro modeling of bile duct development and diseases. However, the cystic organoids lack the branching morphology of intrahepatic bile...
7.
Willemse J, van Tienderen G, van Hengel E, Schurink I, van der Ven D, Kan Y, et al.
Biomaterials
. 2022 Mar;
284:121473.
PMID: 35344800
Human cholangiocyte organoids are promising for regenerative medicine applications, such as repair of damaged bile ducts. However, organoids are typically cultured in mouse tumor-derived basement membrane extracts (BME), which is...
8.
Willemse J, van der Laan L, De Jonge J, Verstegen M
Bioengineering (Basel)
. 2022 Mar;
9(3).
PMID: 35324799
Organoid technology holds great promise for regenerative medicine. Recent studies show feasibility for bile duct tissue repair in humans by successfully transplanting cholangiocyte organoids in liver grafts during perfusion. Large-scale...
9.
Roos F, Wu H, Willemse J, Lieshout R, Albarinos L, Kan Y, et al.
Clin Transl Med
. 2021 Dec;
11(12):e566.
PMID: 34954911
The well-established 3D organoid culture method enabled efficient expansion of cholangiocyte-like cells from intrahepatic (IHBD) and extrahepatic bile duct (EHBD) tissue biopsies. The extensive expansion capacity of these organoids enables...
10.
Schurink I, de Haan J, Willemse J, Mueller M, Doukas M, Roest H, et al.
Sci Rep
. 2021 Dec;
11(1):23444.
PMID: 34873187
No single reliable parameter exists to assess liver graft function of extended criteria donors during ex-vivo normothermic machine perfusion (NMP). The liver maximum capacity (LiMAx) test is a clinically validated...