Ru Chih C Huang
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Explore the profile of Ru Chih C Huang including associated specialties, affiliations and a list of published articles.
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19
Citations
238
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Recent Articles
1.
Chun J, Kimura K, Rajput M, Hsu M, Liang Y, Shanbhag A, et al.
Curr Issues Mol Biol
. 2024 Nov;
46(11):12481-12496.
PMID: 39590335
This study provides evidence to support the concept proposed by Kimura et al. in 2023 that the inhibitors of SP1, MYC, and HIF1A should induce strong anticancer activity by reducing...
2.
Kimura K, Jackson T, Huang R
Curr Issues Mol Biol
. 2023 Nov;
45(11):9262-9283.
PMID: 37998757
Specificity protein 1 (SP1), hypoxia-inducible factor 1 (HIF-1), and MYC are important transcription factors (TFs). SP1, a constitutively expressed housekeeping gene, regulates diverse yet distinct biological activities; MYC is a...
3.
Kimura K, Chun J, Lin Y, Liang Y, Jackson T, Huang R
PLoS One
. 2023 May;
18(5):e0285536.
PMID: 37228120
Tetra-O-methyl-nordihydroguaiaretic acid (terameprocol; M4N), a global transcription inhibitor, in combination with a second anticancer drug induces strong tumoricidal activity and has the ability to suppress energy metabolism in cultured cancer...
4.
Lin Y, Tsai N, Hsieh C, Ho S, Chang J, Wu H, et al.
Proc Natl Acad Sci U S A
. 2016 Nov;
113(48):E7798-E7807.
PMID: 27856749
Cancer progression is associated with the development of antitumor autoantibodies in patients' sera. Although passive treatment with antitumor antibodies has exhibited remarkable therapeutic efficacy, inhibitory effects on tumor progression by...
5.
Kimura K, Huang R
PLoS One
. 2016 Feb;
11(2):e0148685.
PMID: 26886430
The ability of Tetra-O-methyl nordihydroguaiaretic acid (M4N) to induce rapid cell death in combination with Etoposide, Rapamycin, or UCN-01 was examined in LNCaP cells, both in cell culture and animal...
6.
Hsu M, Wu S, Pao K, Unlu I, Gnabre J, Mold D, et al.
ChemMedChem
. 2014 Mar;
9(5):1030-7.
PMID: 24648164
Cancer has been a primary global health issue for decades, with hepatocellular carcinoma (HCC) resulting in more than half a million new cases annually. With survival rates as low as...
7.
Hwu J, Hsu C, Hsu M, Liang Y, Huang R, Lee Y
Bioorg Med Chem Lett
. 2010 Dec;
21(1):380-2.
PMID: 21123067
Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)(4) (12b) and NDGA-(triazol-glucose)(4) (12c) were found...
8.
Wang A, Leong S, Liang Y, Huang R, Chen C, Yu S
Biomacromolecules
. 2008 Sep;
9(10):2929-36.
PMID: 18816098
Angiogenesis, a morphogenic event endothelial cells (ECs) undergo in response to 3-D environmental triggers, is critical to the survival and ultimate functional capacity of engineered tissue constructs. Here we present...
9.
Hwu J, Hsu M, Huang R
Bioorg Med Chem Lett
. 2008 Mar;
18(6):1884-8.
PMID: 18321703
Reaction of nordihydroguaiaretic acid with various alkyl chloride, 1-piperidinecarbonyl chloride, methyl chloroformate, or 1,1'-carbonyldiimidazole under alkaline conditions produced the corresponding phenol ethers, carbamates and carbonates, respectively, in 67-83% yields. Among...
10.
Yeh H, Puleo C, Lim T, Ho Y, Giza P, Huang R, et al.
Nucleic Acids Res
. 2006 Nov;
34(21):e144.
PMID: 17108358
The transcription factor (TF) Sp1 is a well-known RNA polymerase II transcription activator that binds to GC-rich recognition sites in a number of essential cellular and viral promoters. In addition,...