Roy N Alcalay
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Explore the profile of Roy N Alcalay including associated specialties, affiliations and a list of published articles.
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227
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5266
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Recent Articles
1.
Somerville E, James A, Beetz C, Schwieger R, Barrel G, Kandaswamy K, et al.
Ann Neurol
. 2025 Mar;
PMID: 40022584
GBA1 variants and decreased glucocerebrosidase activity are implicated in Parkinson's disease (PD). We investigated the hypothesis that increased levels of glucosylceramide (GlcCer), a main substrate of glucocerebrosidase, are involved in...
2.
Tan M, Iwaki H, Bandres-Ciga S, Sosero Y, Shoai M, Brockmann K, et al.
medRxiv
. 2025 Feb;
PMID: 39974079
Polygenic risk scores (PRS) in Parkinson's disease (PD) are associated with disease risk. Recently, pathway-specific PRS have been created to take advantage of annotations inking variants to biological pathways or...
3.
Goldstein O, Shani S, Gana-Weisz M, Elkoshi N, Casey F, Sun Y, et al.
J Parkinsons Dis
. 2025 Feb;
:1877718X241310722.
PMID: 39973498
Background: While and variants are associated with Parkinson's disease (PD), most carriers will not develop the disease. Objective: To test if polygenic risk score (PRS) modifies disease risk and phenotypes...
4.
Shani S, Gana-Weisz M, Bar-Shira A, Thaler A, Gurevich T, Mirelman A, et al.
J Parkinsons Dis
. 2025 Feb;
14(8):1575-1583.
PMID: 39957192
Background: The adaptive immune response has a role in Parkinson's disease (PD). Patients with or mutations often exhibit distinct clinical characteristics. Objective: To evaluate the involvement of adaptive immune response...
5.
Rossi M, Schaake S, Usnich T, Boehm J, Steffen N, Schell N, et al.
Mov Disord
. 2025 Feb;
PMID: 39927608
Depending on zygosity and the specific change, different variants in the GBA1 gene can cause Parkinson's disease (PD, PARK-GBA1) with reduced penetrance, act as genetic risk factors for PD or...
6.
Soto C, Mollenhauer B, Hansson O, Kang U, Alcalay R, Standaert D, et al.
Nat Med
. 2025 Jan;
31(2):396-408.
PMID: 39885358
Cerebral accumulation of alpha-synuclein (αSyn) aggregates is the hallmark event in a group of neurodegenerative diseases-collectively called synucleinopathies-which include Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. Currently,...
7.
Tan A, Saffie-Awad P, Schumacher Schuh A, Lim S, Madoev H, Ahmad-Annuar A, et al.
Neurol Genet
. 2025 Jan;
10(6):e200213.
PMID: 39807215
Background And Objectives: In the era of precision medicine, genetic test results have become increasingly relevant in the care of patients with Parkinson disease (PD). While large research consortia are...
8.
Droby A, Yoffe-Vasiliev A, Atias D, Fraser K, Mabrouk O, Omer N, et al.
NPJ Parkinsons Dis
. 2025 Jan;
11(1):7.
PMID: 39753572
Alpha-synuclein (αS) aggregation is a widely regarded hallmark of Parkinson's disease (PD) and can be detected through synuclein amplification assays (SAA). This study investigated the association between cerebrospinal fluid (CSF)...
9.
Weintraub D, Nair A, Kurth R, Brumm M, York M, Dobkin R, et al.
medRxiv
. 2024 Dec;
PMID: 39711699
Objectives: To determine the impact of dopamine deficiency and isolated REM sleep behavior disorder (iRBD) on cognitive performance in early neuronal alpha-synuclein disease (NSD) with hyposmia. Methods: Using Parkinson's Progression...
10.
Jones-Tabah J, He K, Karpilovsky N, Senkevich K, Deyab G, Pietrantonio I, et al.
Mol Neurodegener
. 2024 Dec;
19(1):94.
PMID: 39696367
No abstract available.