Roy M Daniel
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Explore the profile of Roy M Daniel including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
285
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Recent Articles
1.
Daniel R, Danson M
FEBS Lett
. 2013 Jul;
587(17):2738-43.
PMID: 23810865
The discovery of an additional step in the progression of an enzyme from the active to inactive state under the influence of temperature has led to a better match with...
2.
Lee C, Monk C, Daniel R
Methods Mol Biol
. 2013 Mar;
996:219-30.
PMID: 23504427
Of the two independent processes by which enzymes lose activity with increasing temperature, irreversible thermal inactivation and rapid reversible equilibration with an inactive form, the latter is only describable by...
3.
Rogers T, Daniel R, Bommarius A
ChemCatChem
. 2011 Nov;
1(1):131-137.
PMID: 22039393
The thermal deactivation of TEM-1 β-lactamase was examined using two experimental techniques: a series of isothermal batch assays and a single, continuous, non-isothermal assay in an enzyme membrane reactor (EMR)....
4.
Hobbs J, Shepherd C, Saul D, Demetras N, Haaning S, Monk C, et al.
Mol Biol Evol
. 2011 Oct;
29(2):825-35.
PMID: 21998276
Thermophily is thought to be a primitive trait, characteristic of early forms of life on Earth, that has been gradually lost over evolutionary time. The genus Bacillus provides an ideal...
5.
Lopez M, Kurkal-Siebert V, Dunn R, Tehei M, Finney J, Smith J, et al.
Biophys J
. 2010 Oct;
99(8):L62-4.
PMID: 20959076
Water is widely assumed to be essential for life, although the exact molecular basis of this requirement is unclear. Water facilitates protein motions, and although enzyme activity has been demonstrated...
6.
Daniel R, Danson M
Trends Biochem Sci
. 2010 Jun;
35(10):584-91.
PMID: 20554446
The two established thermal properties of enzymes are their activation energy and their thermal stability, but experimental data do not match the expectations of these two properties. The recently proposed...
7.
Daniel R, Peterson M, Danson M, Price N, Kelly S, Monk C, et al.
Biochem J
. 2009 Oct;
425(2):353-60.
PMID: 19849667
Experimental data show that the effect of temperature on enzymes cannot be adequately explained in terms of a two-state model based on increases in activity and denaturation. The Equilibrium Model...
8.
Lee C, Cary S, Murray A, Daniel R
Appl Environ Microbiol
. 2007 Dec;
74(3):774-82.
PMID: 18083873
The equilibrium model, which describes the influence of temperature on enzyme activity, has been established as a valid and useful tool for characterizing enzyme eurythermalism and thermophily. By introducing K(eq),...
9.
Daniel R, Danson M, Eisenthal R, Lee C, Peterson M
Extremophiles
. 2007 Sep;
12(1):51-9.
PMID: 17849082
The two established thermal properties of enzymes are their activation energy and their thermal stability. Arising from careful measurements of the thermal behaviour of enzymes, a new model, the Equilibrium...
10.
Lee C, Daniel R, Shepherd C, Saul D, Cary S, Danson M, et al.
FASEB J
. 2007 Mar;
21(8):1934-41.
PMID: 17341686
The "Equilibrium Model" has provided new tools for describing and investigating enzyme thermal adaptation. It has been shown that the effect of temperature on enzyme activity is not only governed...