Michael J Danson
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Explore the profile of Michael J Danson including associated specialties, affiliations and a list of published articles.
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51
Citations
730
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Recent Articles
1.
Hindson S, Andrews R, Danson M, van der Kamp M, Manley A, Sutcliffe O, et al.
FEBS J
. 2023 Jan;
290(12):3243-3257.
PMID: 36708234
Synthetic cannabinoid receptor agonists (SCRAs) are one of the fastest growing classes of recreational drugs. Despite their growth in use, their vast chemical diversity and rapidly changing landscape of structures...
2.
Royer S, Gao X, Groleau R, van der Kamp M, Bull S, Danson M, et al.
ACS Catal
. 2022 Sep;
12(18):11444-11455.
PMID: 36158901
A 2-keto-3-deoxygluconate aldolase from the hyperthermophile catalyzes the nonstereoselective aldol reaction of pyruvate and d-glyceraldehyde to produce 2-keto-3-deoxygluconate (d-KDGlc) and 2-keto-3-deoxy-d-galactonate (d-KDGal). Previous investigations into curing the stereochemical promiscuity of...
3.
Van Wyk J, Sewell B, Danson M, Tsekoa T, Sayed M, Cowan D
Curr Res Struct Biol
. 2022 Sep;
4:256-270.
PMID: 36106339
Nitrile hydratases (NHases) are important biocatalysts for the enzymatic conversion of nitriles to industrially-important amides such as acrylamide and nicotinamide. Although thermostability in this enzyme class is generally low, there...
4.
Winter S, Jones H, Rasadean D, Crean R, Danson M, Pantos G, et al.
ACS Catal
. 2021 Dec;
11(24):14854-14863.
PMID: 34956689
Uncovering the role of global protein dynamics in enzyme turnover is needed to fully understand enzyme catalysis. Recently, we have demonstrated that the heat capacity of catalysis, Δ , can...
5.
Holland A, Danson M, Bolhuis A
BMC Biotechnol
. 2019 Mar;
19(1):17.
PMID: 30894163
Background: Parageobacillus thermoglucosidasius is a thermophilic and ethanol-producing bacterium capable of utilising both hexose and pentose sugars for fermentation. The organism has been proposed to be a suitable organism for...
6.
Zaitsev V, Johnsen U, Reher M, Ortjohann M, Taylor G, Danson M, et al.
Biochemistry
. 2018 May;
57(26):3797-3806.
PMID: 29812914
The thermoacidophilic archaea Picrophilus torridus and Sulfolobus solfataricus catabolize glucose via a nonphosphorylative Entner-Doudoroff pathway and a branched Entner-Doudoroff pathway, respectively. Key enzymes for these Entner-Doudoroff pathways are the aldolases,...
7.
Buddrus L, Andrews E, Leak D, Danson M, Arcus V, Crennell S
Acta Crystallogr F Struct Biol Commun
. 2018 Mar;
74(Pt 3):179-186.
PMID: 29497023
Pyruvate decarboxylase (PDC; EC 4.1.1.1) is a key enzyme in homofermentative metabolism where ethanol is the major product. PDCs are thiamine pyrophosphate- and Mg ion-dependent enzymes that catalyse the non-oxidative...
8.
Bacon L, Hamley-Bennett C, Danson M, Leak D
Microb Cell Fact
. 2017 Apr;
16(1):58.
PMID: 28381218
Background: Geobacillus thermoglucosidasius is a thermophilic, natural ethanol producer and a potential candidate for commercial bioethanol production. Previously, G. thermoglucosidasius has been genetically modified to create an industrially-relevant ethanol production...
9.
Buddrus L, Andrews E, Leak D, Danson M, Arcus V, Crennell S
Acta Crystallogr F Struct Biol Commun
. 2016 Sep;
72(Pt 9):700-6.
PMID: 27599861
Pyruvate decarboxylase (PDC; EC 4.1.1.1) is a thiamine pyrophosphate- and Mg(2+) ion-dependent enzyme that catalyses the non-oxidative decarboxylation of pyruvate to acetaldehyde and carbon dioxide. It is rare in bacteria,...
10.
Extance J, Danson M, Crennell S
Protein Sci
. 2016 Aug;
25(11):2045-2053.
PMID: 27571338
Acetylating aldehyde dehydrogenases (AcAldDH) catalyse the acetylation of Coenzyme-A (CoA), or in reverse generate acetaldehyde from Acetyl-CoA using NADH as a co-factor. This article reports the expression, purification, enzyme assay,...