Roshni Singaraja
Overview
Explore the profile of Roshni Singaraja including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
518
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0
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Recent Articles
1.
Functional and Multi-Omics Effects of an Optimized CRISPR-Mediated FURIN Depletion in U937 Monocytes
Chua R, Wang L, Singaraja R, Ghosh S
Cells
. 2024 Apr;
13(7.
PMID: 38607027
The pro-protein convertase FURIN (PCSK3) is implicated in a wide range of normal and pathological biological processes such as infectious diseases, cancer and cardiovascular diseases. Previously, we performed a systemic...
2.
Hettiaracchchi D, Bonnard C, Jayawardana S, Ng A, Tohari S, Venkatesh B, et al.
BMC Med Genet
. 2018 Jul;
19(1):125.
PMID: 30041615
Background: Cenani-Lenz Syndactyly (CLS) syndrome is a rare autosomal recessive disorder characterized by syndactyly and oligodactyly of fingers and toes, disorganization and fusion of metacarpals, metatarsals and phalanges, radioulnar synostosis...
3.
Herr K, Tsang Y, Ong J, Li Q, Yap L, Yu W, et al.
Sci Rep
. 2014 Oct;
4:6835.
PMID: 25355493
The liver is unique in its capacity to regenerate after injury, during which hepatocytes actively divide and establish cell-cell contacts through cell adhesion complexes. Here, we demonstrate that the loss...
4.
Rinninger F, Heine M, Singaraja R, Hayden M, Brundert M, Ramakrishnan R, et al.
J Lipid Res
. 2014 Jun;
55(9):1914-24.
PMID: 24954421
The LDL receptor (LDLR) and scavenger receptor class B type I (SR-BI) play physiological roles in LDL and HDL metabolism in vivo. In this study, we explored HDL metabolism in...
5.
Tietjen I, Hovingh G, Singaraja R, Radomski C, McEwen J, Chan E, et al.
Biochim Biophys Acta
. 2011 Aug;
1821(3):416-24.
PMID: 21875686
Mutations in ABCA1, APOA1, and LCAT reduce HDL cholesterol (HDLc) in humans. However, the prevalence of these mutations and their relative effects on HDLc reduction and risk of coronary artery...
6.
Huang K, Sanders S, Kang R, Carroll J, Sutton L, Wan J, et al.
Hum Mol Genet
. 2011 Jun;
20(17):3356-65.
PMID: 21636527
Huntington disease (HD) is caused by polyglutamine expansion in the huntingtin (HTT) protein. Huntingtin-interacting protein 14 (HIP14), one of 23 DHHC domain-containing palmitoyl acyl transferases (PATs), binds to HTT and...
7.
Kang M, Singaraja R, Hayden M
Trends Cardiovasc Med
. 2010 Jul;
20(2):41-9.
PMID: 20656214
Mutations in the adenosine-triphosphate-binding cassette transporter-1 (ABCA1) lead to Tangier disease, a genetic disorder characterized by an almost complete absence of plasma high-density lipoprotein cholesterol. Although the importance of ABCA1...
8.
Huang K, Sanders S, Singaraja R, Orban P, Cijsouw T, Arstikaitis P, et al.
FASEB J
. 2009 Mar;
23(8):2605-15.
PMID: 19299482
Palmitoylation, a post-translational modification of cysteine residues with the lipid palmitate, has recently emerged as an important mechanism for regulating protein trafficking and function. With the identification of 23 DHHC...
9.
Wellington C, Yang Y, Zhou S, Clee S, Tan B, Hirano K, et al.
J Lipid Res
. 2002 Oct;
43(11):1939-49.
PMID: 12401893
Mutations in ABCA1 uniformly decrease plasma HDL-cholesterol (HDL-C) and reduce cholesterol efflux, yet different mutations in ABCA1 result in different phenotypic effects in heterozygotes. For example, truncation mutations result in...
10.
Wellington C, Ellerby L, Gutekunst C, Rogers D, Warby S, Graham R, et al.
J Neurosci
. 2002 Sep;
22(18):7862-72.
PMID: 12223539
Huntington's disease (HD) results from polyglutamine expansion in huntingtin (htt), a protein with several consensus caspase cleavage sites. Despite the identification of htt fragments in the brain, it has not...