Roshini Sathiaseelan
Overview
Explore the profile of Roshini Sathiaseelan including associated specialties, affiliations and a list of published articles.
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14
Citations
239
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Recent Articles
1.
Sathiaseelan R, Isola J, Santin-Marquez R, Adekunbi D, Fornalik M, Salmon A, et al.
Geroscience
. 2024 Aug;
47(1):1005-1017.
PMID: 39107620
17α-estradiol extends healthspan and lifespan in male mice without significant feminization or deleterious effects on reproductive function, making it a candidate for human translation. However, studies in animal models that...
2.
Ali Mondal S, Mann S, van der Linden C, Sathiaseelan R, Kamal M, Das S, et al.
Sci Rep
. 2023 Jun;
13(1):9841.
PMID: 37330610
Metabolic dysfunction underlies several chronic diseases. Dietary interventions can reverse metabolic declines and slow aging but remaining compliant is difficult. 17α-estradiol (17α-E2) treatment improves metabolic parameters and slows aging in...
3.
Ali Mondal S, Mann S, van der Linden C, Sathiaseelan R, Kamal M, Das S, et al.
bioRxiv
. 2023 Mar;
PMID: 36993459
Metabolic dysfunction underlies several chronic diseases. Dietary interventions can reverse metabolic declines and slow aging but remaining compliant is difficult. 17α-estradiol (17α-E2) treatment improves metabolic parameters and slows aging in...
4.
Sathiaseelan R, Ahn B, Stout M, Logan S, Wanagat J, Nguyen H, et al.
J Gerontol A Biol Sci Med Sci
. 2023 Feb;
78(5):771-779.
PMID: 36762848
We generated a genetically heterogenous rat model by a 4-way cross strategy using 4 inbred strains (Brown Norway [BN], Fischer 344 [F344], Lewis [LEW], and Wistar Kyoto [KY]) to provide...
5.
Ali Mondal S, Sathiaseelan R, Mann S, Kamal M, Luo W, Saccon T, et al.
Am J Physiol Endocrinol Metab
. 2022 Dec;
324(2):E120-E134.
PMID: 36516471
Estrogen signaling is protective against chronic liver diseases, although men and a subset of women are contraindicated for chronic treatment with 17β-estradiol (17β-E2) or combination hormone replacement therapies. We sought...
6.
Liu H, Witzigreuter L, Sathiaseelan R, Agbaga M, Brush R, Stout M, et al.
J Orthop Res
. 2022 Mar;
40(12):2771-2779.
PMID: 35279877
Obesity promotes the development of osteoarthritis (OA). It is also well-established that obesity leads to excessive lipid deposition in nonadipose tissues, which often induces lipotoxicity. The objective of this study...
7.
Ansere V, Ali-Mondal S, Sathiaseelan R, Garcia D, Isola J, Henseb J, et al.
Mech Ageing Dev
. 2020 Dec;
194:111425.
PMID: 33383072
Decline in ovarian reserve with advancing age is associated with reduced fertility and the emergence of metabolic disturbances, osteoporosis, and neurodegeneration. Recent studies have provided insight into connections between ovarian...
8.
Mann S, Hadad N, Nelson Holte M, Rothman A, Sathiaseelan R, Ali Mondal S, et al.
Elife
. 2020 Dec;
9.
PMID: 33289482
Metabolic dysfunction underlies several chronic diseases, many of which are exacerbated by obesity. Dietary interventions can reverse metabolic declines and slow aging, although compliance issues remain paramount. 17α-estradiol treatment improves...
9.
Mann S, Pitel K, Nelson-Holte M, Iwaniec U, Turner R, Sathiaseelan R, et al.
Exp Gerontol
. 2020 Oct;
142:111113.
PMID: 33065227
Menopause is a natural physiological process in older women that is associated with reduced estrogen production and results in increased risk for obesity, diabetes, and osteoporosis. 17α-estradiol (17α-E2) treatment in...
10.
Sidhom S, Schneider A, Fang Y, McFadden S, Darcy J, Sathiaseelan R, et al.
J Gerontol A Biol Sci Med Sci
. 2020 Aug;
76(5):778-785.
PMID: 32857104
Aging is the greatest risk factor for most chronic diseases. The somatotropic axis is one of the most conserved biological pathways that regulates aging across species. 17α-Estradiol (17α-E2), a diastereomer...