Rosalyn Ram
Overview
Explore the profile of Rosalyn Ram including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
1005
Followers
0
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Recent Articles
1.
Zollinger D, Rivers E, Fine A, Huang Y, Son J, Kalyan A, et al.
PLoS One
. 2024 May;
19(5):e0302129.
PMID: 38753705
Emerging technologies focused on the detection and quantification of circulating tumor DNA (ctDNA) in blood show extensive potential for managing patient treatment decisions, informing risk of recurrence, and predicting response...
2.
Kalashnikova E, Aushev V, Malashevich A, Tin A, Krinshpun S, Salari R, et al.
Mol Oncol
. 2023 Dec;
18(11):2649-2657.
PMID: 38037739
Several studies have demonstrated the prognostic value of circulating tumor DNA (ctDNA); however, the correlation of mean tumor molecules (MTM)/ml of plasma and mean variant allele frequency (mVAF; %) with...
3.
Christensen E, Birkenkamp-Demtroder K, Sethi H, Shchegrova S, Salari R, Nordentoft I, et al.
J Clin Oncol
. 2019 May;
37(18):1547-1557.
PMID: 31059311
Purpose: Novel sensitive methods for early detection of relapse and for monitoring therapeutic efficacy may have a huge impact on risk stratification, treatment, and ultimately outcome for patients with bladder...
4.
Altug Y, Liang N, Ram R, Ravi H, Ahmed E, Brevnov M, et al.
Transplantation
. 2019 Feb;
103(12):2657-2665.
PMID: 30801536
Background: Early detection of rejection in kidney transplant recipients holds the promise to improve clinical outcomes. Development and implementation of more accurate, noninvasive methods to detect allograft rejection remain an...
5.
Ou Y, Torres M, Ram R, Formstecher E, Roland C, Cheng T, et al.
Mol Cell
. 2011 Feb;
41(4):458-70.
PMID: 21329883
The innate immune-signaling kinase, TBK1, couples pathogen surveillance to induction of host defense mechanisms. Pathological activation of TBK1 in cancer can overcome programmed cell death cues, enabling cells to survive...
6.
Whitehurst A, Ram R, Shivakumar L, Gao B, Minna J, White M
Mol Cell Biol
. 2008 Mar;
28(10):3190-7.
PMID: 18347058
Multiple molecular lesions in human cancers directly collaborate to deregulate proliferation and suppress apoptosis to promote tumorigenesis. The candidate tumor suppressor RASSF1A is commonly inactivated in a broad spectrum of...
7.
Beane R, Ram R, Gabillet S, Arar K, Monia B, Corey D
Biochemistry
. 2007 Jun;
46(25):7572-80.
PMID: 17536839
Oligonucleotides containing locked nucleic acid bases (LNAs) have increased affinity for complementary DNA sequences. We hypothesized that enhanced affinity might allow LNAs to recognize chromosomal DNA inside human cells and...
8.
Janowski B, Younger S, Hardy D, Ram R, Huffman K, Corey D
Nat Chem Biol
. 2007 Jan;
3(3):166-73.
PMID: 17259978
The ability to selectively activate or inhibit gene expression is fundamental to understanding complex cellular systems and developing therapeutics. Recent studies have demonstrated that duplex RNAs complementary to promoters within...
9.
Janowski B, Huffman K, Schwartz J, Ram R, Nordsell R, Shames D, et al.
Nat Struct Mol Biol
. 2006 Aug;
13(9):787-92.
PMID: 16936728
Duplex RNAs complementary to messenger RNA inhibit translation in mammalian cells by RNA interference (RNAi). Studies have reported that RNAs complementary to promoter DNA also inhibit gene expression. Here we...
10.
Janowski B, Huffman K, Schwartz J, Ram R, Hardy D, Shames D, et al.
Nat Chem Biol
. 2006 Jan;
1(4):216-22.
PMID: 16408038
Transcription start sites are critical switches for converting recognition of chromosomal DNA into active synthesis of RNA. Their functional importance suggests that they may be ideal targets for regulating gene...