Jacob C Schwartz
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Explore the profile of Jacob C Schwartz including associated specialties, affiliations and a list of published articles.
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27
Citations
1776
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Recent Articles
1.
Kuzmina A, Sadhu L, Hasanuzzaman M, Fujinaga K, Schwartz J, Fackler O, et al.
PLoS Pathog
. 2024 Apr;
20(4):e1012172.
PMID: 38662769
The implementation of antiretroviral therapy (ART) has effectively restricted the transmission of Human Immunodeficiency Virus (HIV) and improved overall clinical outcomes. However, a complete cure for HIV remains out of...
2.
Lay M, Thompson V, Adelakun A, Schwartz J
Biopolymers
. 2024 Mar;
115(3):e23576.
PMID: 38511874
EWSR1 (Ewing Sarcoma Related protein 1) is an RNA binding protein that is ubiquitously expressed across cell lines and involved in multiple parts of RNA processing, such as transcription, splicing,...
3.
Lay M, Thompson V, Adelakun A, Schwartz J
bioRxiv
. 2024 Jan;
PMID: 38293191
EWSR1 (Ewing Sarcoma Related protein 1) is an RNA binding protein that is ubiquitously expressed across cell lines and involved in multiple parts of RNA processing, such as transcription, splicing,...
4.
Thompson V, Wieland D, Mendoza-Leon V, Janis H, Lay M, Harrell L, et al.
J Biol Chem
. 2023 Sep;
299(10):105237.
PMID: 37690693
The protein FUS (FUSed in sarcoma) is a metazoan RNA-binding protein that influences RNA production by all three nuclear polymerases. FUS also binds nascent transcripts, RNA processing factors, RNA polymerases,...
5.
Anderson E, Morera A, Kour S, Cherry J, Ramesh N, Gleixner A, et al.
Elife
. 2021 Jun;
10.
PMID: 34060470
Traumatic brain injury (TBI) is a predisposing factor for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and chronic traumatic encephalopathy (CTE). Although defects...
6.
Ahmed N, Harrell L, Wieland D, Lay M, Thompson V, Schwartz J
RNA
. 2021 May;
PMID: 34035145
Ewing sarcoma is driven by fusion proteins containing a low complexity (LC) domain that is intrinsically disordered and a powerful transcriptional regulator. The most common fusion protein found in Ewing...
7.
Victor R, Thompson V, Schwartz J
Curr Protoc
. 2021 Mar;
1(3):e35.
PMID: 33740275
Recent advancements in detection methods have made protein condensates, also called granules, a major area of study, but tools to characterize these assemblies need continued development to keep up with...
8.
Moinpour M, Barker N, Guzman L, Jewett J, Langlais P, Schwartz J
Protein Sci
. 2020 Jun;
29(8):1784-1793.
PMID: 32483864
Chemical modification of proteins has been crucial in engineering protein-based therapies, targeted biopharmaceutics, molecular probes, and biomaterials. Here, we explore the use of a conjugation-based approach to sense alternative conformational...
9.
Kawaguchi T, Rollins M, Moinpour M, Morera A, Ebmeier C, Old W, et al.
J Proteome Res
. 2019 Nov;
19(1):360-370.
PMID: 31693373
The RNA-binding proteins TDP-43 and FUS are tied as the third leading known genetic cause for amyotrophic lateral sclerosis (ALS), and TDP-43 proteopathies are found in nearly all ALS patients....
10.
Morera A, Ahmed N, Schwartz J
Biochim Biophys Acta Gene Regul Mech
. 2019 Oct;
1862(10):194434.
PMID: 31655156
The 43-kDa transactive response DNA-binding protein (TDP-43) is an example of an RNA-binding protein that regulates RNA metabolism at multiple levels from transcription and splicing to translation. Its role in...