Rosa M Nevado
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Explore the profile of Rosa M Nevado including associated specialties, affiliations and a list of published articles.
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11
Citations
269
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Recent Articles
1.
Benedicto I, Hamczyk M, Nevado R, Barettino A, Carmona R, Espinos-Estevez C, et al.
Aging Cell
. 2024 Oct;
24(2):e14389.
PMID: 39479939
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by a mutation in the LMNA gene that provokes the synthesis of progerin, a mutant version of the nuclear protein...
2.
Hamczyk M, Nevado R, Gonzalo P, Andres-Manzano M, Nogales P, Quesada V, et al.
Circulation
. 2024 Aug;
150(20):1612-1630.
PMID: 39206565
Background: Atherosclerosis is the main medical problem in Hutchinson-Gilford progeria syndrome, a rare premature aging disorder caused by the mutant lamin-A protein progerin. Recently, we found that limiting progerin expression...
3.
Benedicto I, Carmona R, Barettino A, Espinos-Estevez C, Gonzalo P, Nevado R, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(18):e2400752121.
PMID: 38648484
Hutchinson-Gilford progeria syndrome (HGPS) is a rare disease caused by the expression of progerin, a mutant protein that accelerates aging and precipitates death. Given that atherosclerosis complications are the main...
4.
Macias A, Nevado R, Gonzalez-Gomez C, Gonzalo P, Andres-Manzano M, Dorado B, et al.
Geroscience
. 2023 May;
46(1):867-884.
PMID: 37233881
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disease caused by expression of progerin, a lamin A variant that is also expressed at low levels in non-HGPS individuals. Although...
5.
Nevado R, Hamczyk M, Andres V
Methods Mol Biol
. 2022 Mar;
2419:611-627.
PMID: 35237992
Aging is associated with alterations in the arterial wall that promote vascular disease development and its clinical manifestations, including myocardial infarction, stroke, and arterial dissection. The arterial wall is comprised...
6.
Hamczyk M, Nevado R
Clin Investig Arterioscler
. 2022 Feb;
35(1):42-51.
PMID: 35125249
Vascular smooth muscle cells (VSMCs) constitute the principal cellular component of the medial layer of arteries and are responsible for vessel contraction and relaxation in response to blood flow. Alterations...
7.
De Majo F, Martens L, Hegenbarth J, Ruhle F, Hamczyk M, Nevado R, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(36).
PMID: 34465617
Genomic instability, the unresolved accumulation of DNA variants, is hypothesized as one of the contributors to the natural aging process. We assessed the frequency of unresolved DNA damage reaching the...
8.
Nevado R, Hamczyk M, Gonzalo P, Andres-Manzano M, Andres V
Cells
. 2020 Oct;
9(10).
PMID: 33049978
Hutchinson-Gilford progeria syndrome (HGPS) is among the most devastating of the laminopathies, rare genetic diseases caused by mutations in genes encoding nuclear lamina proteins. HGPS patients age prematurely and die...
9.
Bar C, Chatterjee S, Pires I, Rodrigues P, Sluijter J, Boon R, et al.
Cardiovasc Res
. 2020 Jul;
116(11):1805-1819.
PMID: 32638021
Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that...
10.
Hamczyk M, Nevado R, Barettino A, Fuster V, Andres V
J Am Coll Cardiol
. 2020 Mar;
75(8):919-930.
PMID: 32130928
Aging is the main risk factor for vascular disease and ensuing cardiovascular and cerebrovascular events, the leading causes of death worldwide. In a progressively aging population, it is essential to...