Kristin L Granlund
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Explore the profile of Kristin L Granlund including associated specialties, affiliations and a list of published articles.
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16
Citations
413
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Recent Articles
1.
Miloushev V, Boltyanskiy R, Granlund K, Keshari K
MAGMA
. 2022 Jul;
35(6):895-901.
PMID: 35876917
Object: Spatial variation in the sensitivity profiles of receive coils in MRI leads to spatially dependent scaling of the signal amplitude across an image. In practice, total sensitivity of the...
2.
Eskandari R, Kim N, Mamakhanyan A, Saoi M, Zhang G, Berisaj M, et al.
Proc Natl Acad Sci U S A
. 2022 May;
119(19):e2120595119.
PMID: 35512101
Glutamine is consumed by rapidly proliferating cells and can provide the carbon and nitrogen required for growth through various metabolic pathways. However, delineating the metabolic fate of glutamine is challenging...
3.
Lees H, Millan M, Ahamed F, Eskandari R, Granlund K, Jeong S, et al.
NMR Biomed
. 2020 Dec;
34(3):e4447.
PMID: 33314422
Hyperpolarized [1- C] pyruvate can be used to examine the metabolic state of cancer cells, highlighting a key metabolic characteristic of cancer: the upregulated metabolic flux to lactate, even in...
4.
Deh K, Granlund K, Eskandari R, Kim N, Mamakhanyan A, Keshari K
Magn Reson Med
. 2020 Aug;
85(2):978-986.
PMID: 32820566
Purpose: To generate dynamic, volumetric maps of hyperpolarized [1- C]pyruvate and its metabolic products in vivo. Methods: Maps of chemical species were generated with iterative least squares (IDEAL) reconstruction from...
5.
Granlund K, Tee S, Vargas H, Lyashchenko S, Reznik E, Fine S, et al.
Cell Metab
. 2019 Oct;
31(1):105-114.e3.
PMID: 31564440
Metabolic imaging using hyperpolarized magnetic resonance can increase the sensitivity of MRI, though its ability to inform on relevant changes to biochemistry in humans remains unclear. In this work, we...
6.
Cho A, Eskandari R, Granlund K, Keshari K
ACS Chem Biol
. 2019 Mar;
14(4):665-673.
PMID: 30893552
Alterations in arginase enzyme expression are linked with various diseases and have been shown to support disease progression, thus motivating the development of an imaging probe for this enzymatic target....
7.
Dong Y, Eskandari R, Ray C, Granlund K, Santos-Cunha L, Miloushev V, et al.
Cancer Res
. 2018 Nov;
79(1):242-250.
PMID: 30459151
The ever-changing tumor microenvironment constantly challenges individual cancer cells to balance supply and demand, presenting tumor vulnerabilities and therapeutic opportunities. Everolimus and temsirolimus are inhibitors of mTOR (mTORi) approved for...
8.
Miloushev V, Granlund K, Boltyanskiy R, Lyashchenko S, DeAngelis L, Mellinghoff I, et al.
Cancer Res
. 2018 May;
78(14):3755-3760.
PMID: 29769199
Hyperpolarized (HP) MRI using [1-13C] pyruvate is a novel method that can characterize energy metabolism in the human brain and brain tumors. Here, we present the first dynamically acquired human...
9.
Salamanca-Cardona L, Shah H, Poot A, Correa F, Di Gialleonardo V, Lui H, et al.
Cell Metab
. 2017 Oct;
26(6):830-841.e3.
PMID: 29056515
The oncometabolite 2-hydroxyglutarate (2-HG) is a signature biomarker in various cancers, where it accumulates as a result of mutations in isocitrate dehydrogenase (IDH). The metabolic source of 2-HG, in a...
10.
Miloushev V, Di Gialleonardo V, Salamanca-Cardona L, Correa F, Granlund K, Keshari K
J Magn Reson
. 2017 Jan;
275:120-126.
PMID: 28061381
The expected signal in echo-planar spectroscopic imaging experiments was explicitly modeled jointly in spatial and spectral dimensions. Using this as a basis, absorptive-mode type detection can be achieved by appropriate...