Ronald J Hause
Overview
Explore the profile of Ronald J Hause including associated specialties, affiliations and a list of published articles.
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17
Citations
1479
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Recent Articles
1.
Long D, Waalkes A, Panicker V, Hause R, Salipante S
Clin Chem
. 2020 Oct;
66(10):1310-1318.
PMID: 33001187
Background: Microsatellite instability (MSI) predicts oncological response to checkpoint blockade immunotherapies. Although microsatellite mutation is pathognomonic for the condition, loci have unequal diagnostic value for predicting MSI within and across...
2.
Qin J, Johnstone T, Baturevych A, Hause R, Ragan S, Clouser C, et al.
J Immunother
. 2020 Jan;
43(4):107-120.
PMID: 31899702
Chimeric antigen receptor (CAR) T-cell therapy is a promising treatment for patients with CD19 B-cell malignancies. Combination strategies that improve CAR T-cell potency, limit tumor environment-mediated immune dysfunction, and directly...
3.
Works M, Soni N, Hauskins C, Sierra C, Baturevych A, Jones J, et al.
Mol Cancer Ther
. 2019 Aug;
18(12):2246-2257.
PMID: 31395689
Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cells have shown promising clinical responses in patients with relapsed/refractory multiple myeloma. Lenalidomide, an immunomodulatory drug, potentiates T cell functionality, drives...
4.
Matreyek K, Starita L, Stephany J, Martin B, Chiasson M, Gray V, et al.
Nat Genet
. 2018 May;
50(6):874-882.
PMID: 29785012
Determining the pathogenicity of genetic variants is a critical challenge, and functional assessment is often the only option. Experimentally characterizing millions of possible missense variants in thousands of clinically important...
5.
Hause R, Pritchard C, Shendure J, Salipante S
Nat Med
. 2018 Apr;
24(4):525.
PMID: 29634692
This corrects the article DOI: 10.1038/nm.4191.
6.
Waalkes A, Smith N, Penewit K, Hempelmann J, Konnick E, Hause R, et al.
Clin Chem
. 2018 Apr;
64(6):950-958.
PMID: 29632127
Background: Microsatellite instability (MSI) is an emerging actionable phenotype in oncology that informs tumor response to immune checkpoint pathway immunotherapy. However, there remains a need for MSI diagnostics that are...
7.
Gray V, Hause R, Luebeck J, Shendure J, Fowler D
Cell Syst
. 2017 Dec;
6(1):116-124.e3.
PMID: 29226803
Large datasets describing the quantitative effects of mutations on protein function are becoming increasingly available. Here, we leverage these datasets to develop Envision, which predicts the magnitude of a missense...
8.
Hause R, Pritchard C, Shendure J, Salipante S
Nat Med
. 2017 Oct;
23(10):1241.
PMID: 28985213
This corrects the article DOI: 10.1038/nm.4191.
9.
Gray V, Hause R, Fowler D
Genetics
. 2017 Jul;
207(1):53-61.
PMID: 28751422
Mutagenesis is a widely used method for identifying protein positions that are important for function or ligand binding. Advances in high-throughput DNA sequencing and mutagenesis techniques have enabled measurement of...
10.
Eadon M, Hause R, Stark A, Cheng Y, Wheeler H, Burgess K, et al.
Int J Mol Sci
. 2017 Mar;
18(3).
PMID: 28335481
Colistin sulfate (polymixin E) is an antibiotic prescribed with increasing frequency for severe Gram-negative bacterial infections. As nephrotoxicity is a common side effect, the discovery of pharmacogenomic markers associated with...