Rolf W Warzok
Overview
Explore the profile of Rolf W Warzok including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
430
Followers
0
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Recent Articles
1.
Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice
Brenn A, Grube M, Peters M, Fischer A, Jedlitschky G, Kroemer H, et al.
Int J Alzheimers Dis
. 2011 Jun;
2011:690121.
PMID: 21660212
Neurovascular dysfunction is an important component of Alzheimer's disease, leading to reduced clearance across the blood-brain barrier and accumulation of neurotoxic β-amyloid (Aβ) peptides in the brain. It has been...
2.
Mosyagin I, Runge U, Schroeder H, Dazert E, Vogelgesang S, Siegmund W, et al.
Epilepsia
. 2008 May;
49(9):1555-61.
PMID: 18494787
Purpose: There is evidence from studies in rodents that P-glycoprotein (P-gp) overexpression is implicated in the causation of refractory epilepsy. Genetic variants in the human ABCB1 (MDR1) gene were shown...
3.
May K, Westphal K, Giessmann T, Wegner D, Adam U, Lerch M, et al.
J Clin Pharmacol
. 2008 Mar;
48(5):570-9.
PMID: 18319360
Propiverine extended release is expected to be better tolerated compared to immediate release tablets because of slower drug release and reduced formation of active metabolites in the colon. CYP3A4 and...
4.
Kuhnke D, Jedlitschky G, Grube M, Krohn M, Jucker M, Mosyagin I, et al.
Brain Pathol
. 2007 Jul;
17(4):347-53.
PMID: 17610523
Amyloid-beta (Abeta) is the major component of the insoluble amyloid plaques that accumulate intracerebrally in patients with Alzheimer's disease (AD). It has been suggested that MDR1-P-glycoprotein (ABCB1, P-gp) plays a...
5.
Vogelgesang S, Hippe A, Kessler C, Warzok R
Brain Pathol
. 2006 Nov;
16(4):337-9.
PMID: 17107605
No abstract available.
6.
Vogelgesang S, Glatzel M, Walker L, Kroemer H, Aguzzi A, Warzok R
Acta Neuropathol
. 2006 Mar;
111(5):436-43.
PMID: 16523342
The abnormal conformation and assembly of proteins in the central nervous system is increasingly thought to be a critical pathogenic mechanism in neurodegenerative disorders such as Creutzfeldt-Jakob disease (CJD) and...
7.
Meissner K, Heydrich B, Jedlitschky G, Meyer Zu Schwabedissen H, Mosyagin I, Dazert P, et al.
J Histochem Cytochem
. 2005 Aug;
54(2):215-21.
PMID: 16116030
Efforts to improve severely impaired myocardial function include transplantation of autologous hematopoietic side population (SP) stem cells. The transmembrane ABC-type (ATP binding cassette) half-transporter ABCG2 (BCRP) serves as a marker...
8.
Vogelgesang S, Warzok R, Cascorbi I, Kunert-Keil C, Schroeder E, Kroemer H, et al.
Curr Alzheimer Res
. 2005 Jun;
1(2):121-5.
PMID: 15975076
It has been shown in vitro that beta-amyloid (Abeta) is transported by P-glycoprotein (P-gp). Previously, we demonstrated that Abeta immunoreactivity is significantly elevated in brain tissue of individuals with low...
9.
Meissner K, Jedlitschky G, Meyer Zu Schwabedissen H, Dazert P, Eckel L, Vogelgesang S, et al.
Pharmacogenetics
. 2004 Jul;
14(6):381-5.
PMID: 15247630
Objectives: Variable expression of the ABC-type multidrug resistance membrane protein P-glycoprotein (P-gp, MDR1, ABCB1) in human heart is a potential modulator of drug effects or drug-induced cardiotoxicity. Expression of P-gp...
10.
Vogelgesang S, Cascorbi I, Schroeder E, Pahnke J, Kroemer H, Siegmund W, et al.
Pharmacogenetics
. 2002 Oct;
12(7):535-41.
PMID: 12360104
Deposition of the beta-amyloid peptide (Abeta) in the brain occurs during normal ageing and is substantially accelerated in patients with Alzheimer's disease. Since Abeta is continuously produced in the brain,...