Igor Mosyagin
Overview
Explore the profile of Igor Mosyagin including associated specialties, affiliations and a list of published articles.
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10
Citations
281
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Recent Articles
1.
Mosyagin I, Hellman O, Olovsson W, Simak S, Abrikosov I
J Phys Chem A
. 2016 Oct;
120(43):8761-8768.
PMID: 27700093
Free energy calculations at finite temperature based on ab initio molecular dynamics (AIMD) simulations have become possible, but they are still highly computationally demanding. Besides, achieving simultaneously high accuracy of...
2.
Jedlitschky G, Grube M, Mosyagin I, Kroemer H, Vogelgesang S
Curr Pharm Des
. 2013 Jun;
20(10):1523-33.
PMID: 23789959
Molecular transporters that are expressed in brain, especially at the blood-brain barrier (BBB), are increasingly recognized as possible therapeutic targets in the treatment of neurodegenerative disorders such as Alzheimer's disease...
3.
Athanasiou M, Dettling M, Cascorbi I, Mosyagin I, Salisbury B, Pierz K, et al.
J Clin Psychiatry
. 2010 Sep;
72(4):458-63.
PMID: 20868635
Objective: Clozapine is considered to be the most efficacious drug to treat schizophrenia, although it is underutilized, partially due to a side effect of agranulocytosis. This analysis of 74 candidate...
4.
Ufer M, Mosyagin I, Muhle H, Jacobsen T, Haenisch S, Hasler R, et al.
Pharmacogenet Genomics
. 2009 May;
19(5):353-62.
PMID: 19415824
Objective: We aimed to evaluate the association of non-response to antiepileptic pharmacotherapy with the frequency of variant alleles in the drug transporter genes ABCB1 and ABCC2 or in the CYP2C...
5.
Mosyagin I, Runge U, Schroeder H, Dazert E, Vogelgesang S, Siegmund W, et al.
Epilepsia
. 2008 May;
49(9):1555-61.
PMID: 18494787
Purpose: There is evidence from studies in rodents that P-glycoprotein (P-gp) overexpression is implicated in the causation of refractory epilepsy. Genetic variants in the human ABCB1 (MDR1) gene were shown...
6.
Kuhnke D, Jedlitschky G, Grube M, Krohn M, Jucker M, Mosyagin I, et al.
Brain Pathol
. 2007 Jul;
17(4):347-53.
PMID: 17610523
Amyloid-beta (Abeta) is the major component of the insoluble amyloid plaques that accumulate intracerebrally in patients with Alzheimer's disease (AD). It has been suggested that MDR1-P-glycoprotein (ABCB1, P-gp) plays a...
7.
Mosyagin I, Cascorbi I, Schaub R, Kruger T, Dettling M
J Clin Psychopharmacol
. 2005 Sep;
25(5):435-40.
PMID: 16160618
Drug-induced agranulocytosis is a rare but life-threatening side effect which is possibly based on immunogenetic mechanisms. Some studies regarding agranulocytosis induced by the atypical antipsychotic clozapine dealing with HLA subtyping...
8.
Meissner K, Heydrich B, Jedlitschky G, Meyer Zu Schwabedissen H, Mosyagin I, Dazert P, et al.
J Histochem Cytochem
. 2005 Aug;
54(2):215-21.
PMID: 16116030
Efforts to improve severely impaired myocardial function include transplantation of autologous hematopoietic side population (SP) stem cells. The transmembrane ABC-type (ATP binding cassette) half-transporter ABCG2 (BCRP) serves as a marker...
9.
Belogubova E, Kuligina E, Togo A, Karpova M, Ulibina J, Shutkin V, et al.
Cancer Lett
. 2005 Apr;
221(2):177-83.
PMID: 15808403
NAT2 (arylamine N-acetyltransferase 2) polymorphism, being a key determinant of individual variations in acetylation capacity, is suspected to modify the risk of carcinogen-related malignancies. As tobacco smoke and other inhaled...
10.
Mosyagin I, Dettling M, Roots I, Mueller-Oerlinghausen B, Cascorbi I
J Clin Psychopharmacol
. 2004 Nov;
24(6):613-7.
PMID: 15538122
Therapy of the atypical antipsychotic drug clozapine is limited by a comparatively high incidence of agranulocytosis in 0.8% of patients. This severe side effect is possibly based on the clozapine-mediated...