Rolf P G van Heeswijk
Overview
Explore the profile of Rolf P G van Heeswijk including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
29
Citations
1044
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Pym A, Diacon A, Tang S, Conradie F, Danilovits M, Chuchottaworn C, et al.
Eur Respir J
. 2015 Dec;
47(2):564-74.
PMID: 26647431
Bedaquiline, a diarylquinoline, improved cure rates when added to a multidrug-resistant tuberculosis (MDR-TB) treatment regimen in a previous placebo-controlled, phase 2 trial (TMC207-C208; NCT00449644). The current phase 2, multicenter, open-label,...
2.
Diacon A, Pym A, Grobusch M, de los Rios J, Gotuzzo E, Vasilyeva I, et al.
N Engl J Med
. 2014 Aug;
371(8):723-32.
PMID: 25140958
Background: Bedaquiline (Sirturo, TMC207), a diarylquinoline that inhibits mycobacterial ATP synthase, has been associated with accelerated sputum-culture conversion in patients with multidrug-resistant tuberculosis, when added to a preferred background regimen...
3.
McLeay S, Vis P, van Heeswijk R, Green B
Antimicrob Agents Chemother
. 2014 Jun;
58(9):5315-24.
PMID: 24957842
Bedaquiline is a novel agent for the treatment of pulmonary multidrug-resistant Mycobacterium tuberculosis infections, in combination with other agents. The objective of this study was to develop a population pharmacokinetic...
4.
Crauwels H, van Heeswijk R, Vandevoorde A, Buelens A, Stevens M, Hoetelmans R
J Clin Pharmacol
. 2013 Nov;
54(2):133-40.
PMID: 24203510
Antiretrovirals may influence methadone exposure in HIV-1-infected patients receiving methadone for opiate addiction. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor for treating HIV-1 infection. In this open-label trial (NCT00744770), 13...
5.
Crauwels H, van Heeswijk R, Buelens A, Stevens M, Hoetelmans R
Int J Clin Pharmacol Ther
. 2013 Oct;
52(2):118-28.
PMID: 24161160
Unlabelled: Rilpivirine is a human immunodeficiency virus Type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitor. Objective: Rilpivirine metabolism involves cytochrome P450 3A4 (CYP3A4). This trial (ClinicalTrials. gov number: NCT00739622) evaluated the...
6.
Crauwels H, van Heeswijk R, Buelens A, Stevens M, Boven K, Hoetelmans R
J Clin Pharmacol
. 2013 May;
53(8):834-40.
PMID: 23720136
The objective of the study was to determine the impact of food and different meal types on the pharmacokinetics of rilpivirine, a nonnucleoside reverse transcriptase inhibitor. In this open-label, randomized,...
7.
Crauwels H, van Heeswijk R, Stevens M, Buelens A, Vanveggel S, Boven K, et al.
AIDS Rev
. 2013 May;
15(2):87-101.
PMID: 23681436
Rilpivirine (TMC278) is a non-nucleoside reverse transcriptase inhibitor approved in combination with other antiretrovirals for the treatment of HIV-1 infection in treatment-naive adults (Edurant(®) 25 mg once daily; Complera(®) [USA]/Eviplera(®)...
8.
van Heeswijk R, Beumont M, Kauffman R, Garg V
Antivir Ther
. 2013 Jan;
18(4):553-60.
PMID: 23344266
HCV infection is a major cause of mortality worldwide. HCV-related deaths also represent a leading cause of mortality in HIV-coinfected individuals. Telaprevir is an NS3/4A protease inhibitor approved for the...
9.
Pol S, Aerssens J, Zeuzem S, Andreone P, Lawitz E, Roberts S, et al.
J Hepatol
. 2013 Jan;
58(5):883-9.
PMID: 23321318
Background & Aims: Nucleotide polymorphisms upstream of the interleukin 28B (IL28B) gene are strongly associated with hepatitis C virus (HCV) clearance in treatment-naïve patients treated with peginterferon/ribavirin (PegIFN/RBV). This subanalysis...
10.
Garg V, Kauffman R, Beaumont M, van Heeswijk R
Antivir Ther
. 2012 Sep;
17(7):1211-21.
PMID: 22954756
Telaprevir is an inhibitor of the HCV NS3/4A protease. When used in combination with pegylated interferon and ribavirin, telaprevir has demonstrated a substantial increase in sustained virological response compared with...